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Projects
Planned projects only
In progress
Novel non-invasive approaches to identify biomarkers of response to immunotherapies in non-small cell lung cancer
01 / 01 / 2019
Project Objectives Recently, the therapeutic scenario of advanced non-small cell lung cancer (NSCLC) is changed with the introduction into clinical practice of "immune check-points"...
In progress
Identification of circulating biomarkers predictive of response to immunotherapies in patients with clear cell renal cell carcinoma
01 / 01 / 2018
Project Objectives   Recently, the encouraging results of phase III trials led to the approval of immunotherapy as a second-line treatment in patients with clear cell renal cell ca...
In progress
Effects of new molecular target therapies for renal carcinoma on bone tumor microenvironment
01 / 06 / 2017
Project Objectives Several target therapies have recently been approved for the treatment of metastatic clear cell renal cell carcinoma. These drugs have a strong inhibitory activity for seve...
In progress
Effects of cyclin-dependent kinase inhibitors (CDK4/6) on pre-clinical models of bone metastases from breast cancer
01 / 01 / 2017
Project Objectives Third generation cyclin-dependent kinase inhibitors (CDK4/6), such as ribociclib, palbociclib and abemaciclib, have shown remarkable clinical efficacy and low toxicity prof...
In progress
Identification of new therapeutic targets in castration-resistant prostate cancer
01 / 01 / 2017
Project Objectives Prostate cancer is one of the most common cancers in male and represents about 20% of all cancers diagnosed in humans. Patients with advanced prostate cancer have a high pr...
In progress
Identification of new therapeutic targets in patients affected by trabectedin-resistant soft tissue sarcomas
01 / 01 / 2017
Project Objectives Soft tissue sarcomas are a heterogeneous group of rare solid tumors of mesenchymal origin. Surgical resection is the standard treatment for localized disease, however, abou...
In progress
Identification of molecular and cellular profiles predictive of efficacy to immunotherapies in advanced solid tumors
01 / 09 / 2016
Project Objectives Recently, a paradigm shift in advanced solid tumor therapeutic scenario has occurred thanks to the emerging role of immunotherapies based on the inhibition of the immunolog...
Concluded
Cancer stem cells/immune system interplay
11 / 11 / 2014
Study of cancer stem cells/immune system interplay: innovative cells-on-chip approaches Project Objectives The project aims to clarify the mechanisms of the immune response to cancer st...
Concluded
Integrated therapies based on immunotherapy through macrophage polarization
11 / 11 / 2014
Cells-on-chip models for integrated therapies based on immunotherapy through macrophage polarization: overcoming resistance to conventional treatments for stem compartments in larger cell lung canc...
Concluded
Cells-on-chip technologies for the study of the endocannabinoid system
11 / 11 / 2014
Cells-on-chip technologies for the study of the endocannabinoid system in an in vitro model of tumor / immune system interaction Project objectives The project aims to develop advanced ...