The UCBM Researcher had published his work on the mechanisms at the origin of the pathology in Nature Communications

27 March, 2018 - Less than a year after Copernican revolution in the approach to Alzheimer's disease signed by the researcher UCBM Marcello D'Amelio on Nature Communications, the study by the University of Sheffield arrives to confirm the results on humans.

the manager ofResearch Unit of Molecular Neurosciences UCBM, in collaboration with the IRCCS Santa Lucia Foundation and the CNR of Rome, had in fact highlighted, already in the very early stages of the disease, the progressive death of the neurons of the ventral tegmental area responsible for the production of dopamine, and not of the hippocampus, structure of the central nervous system involved in memory functions, on which instead researchers had focused in the last 20 years.

Following in the footsteps of dopaminergic neurons - on which mood disorders also depend, which for D'Amelio are a spy of Alzheimer's and not a consequence - is today another Italian researcher: Annalena Venneri of the University of Sheffield told that she was interested in the discovery thanks to the echo aroused by the Italian media. Her study, released on Journal of Alzheimer's disease, confirms the researcher's findings UCBM with a trial on patients performed through a 3Tesla magnetic resonance. Closes the circle, as well as the article, a comment by D'Amelio questioned by theeditor in chief of the prestigious scientific journal.

“This clinical study – said prof. D'Amelio - supports my previous observations and urges me to evaluate therapeutic options aimed at protecting the neurons of the ventral tegmental area". In fact, since Parkinson's is also caused by the death of dopamine-producing neurons, it is possible to imagine that future therapeutic strategies for both diseases could focus on a common goal: to 'selectively' prevent the death of these neurons.