The study carried out by Dr. Francesco Pantano, Oncology researcher, in collaboration with INSERM of Lyon

August 2th, 2018 - They regulate gene expression and play a key role in the formation of metastases. MicroRNAs, small RNA molecules, are at the center of the study MicroRNA-30 family members inhibit breast cancer invasion, osteomimicry, and bone destruction by directly targeting multiple bone metastasis-associated genes, conducted by the Medical Oncology Area of ​​the University Hospital in collaboration with Unit 1033 INSERM of Lyon.

The research, published in the prestigious journal Cancer Research and signed in “first co-authorship” by Dr. Francesco Pantano, researcher in the Medical Oncology Area UCBM specialized in Physiopathology of Bone Metastases, and by Dr. Martine Croset, researcher at INSERM Unit 1033 in Lyon, identified a family of small fragments of RNA, the "miRNA 30 family", capable of preventing the spread of bone metastases. 

A work, an expression of the scientific collaboration that has been going on for several years between the Translational Oncology Laboratory directed by profs. Giuseppe Tonini e Daniele Santini and the INSERM Laboratory of Lyon, among the most important centers internationally for the study of bone metastases.

Specifically, the researchers demonstrated that by inducing the expression of miRNA 30 in animals with breast cancer, it is possible to drastically inhibit the invasion of cancer cells into the bones.

The next step will be to study the inhibition of some molecules regulated by miRNA 30 such as lntegrin alpha5 to arrive as quickly as possible at a therapeutic perspective directly applicable in the clinical setting.

>> Read the abstract of the article