Elena Santonico
Biography
Teacher at theUniversità Campus Bio-Medico di Roma, for the teaching activity related to the annual course of “Experimental Biology” in the degree course in Medicine and Surgery “MedTech”. Contract professor at the Department of Biology of the University of Rome Tor Vergata for the teaching of “Mechanisms of cellular degradation” in the degree course in Molecular Genetics of neoplastic transformation of Prof. Luisa Castagnoli. Examination commissioner of the courses “Regenerative Medicine for central nervous system diseases: approaches and future directions” and “Intracellular traffic and human diseases” of Prof. Antonella Ragnini.
Curriculum
2001 - Degree in Molecular and Cellular Biology at the University of Rome Tor Vergata with vote 110/110 cum laude.
2001-2004. PhD in Molecular and Cellular Biology at the University of Rome Tor Vergata in the laboratory of Prof. Gianni Cesareni and Prof. Luisa Castagnoli.
2004-2012. Post-doc at the University of Rome Tor Vergata in the laboratory of Prof. Gianni Cesareni and Prof. Luisa Castagnoli.
2012-2017. Researcher (RTD-A) at the University of Rome Tor Vergata, in the laboratory of Prof. Gianni Cesareni and Prof. Luisa Castagnoli. National scientific qualification (ASN) obtained in the Competition Sector 05/E2, call DD 2175/2018 in Molecular Biology.
2000-present. Referee for Scientific Report, Biomolecules and The FEBS Journal. Guest Editor for Biomolecules (ISSN 2218-273X) for the publication of the volume "Looking Back and Ahead: Emerging Concepts in Ubiquitin and UBLs" published in February 2021.
2014-2019 - Member of the European Cost Action PROTEOSTASIS.
2021- Today – Member of the European Cost Action COST ACTION: "A sound proteome for a sound body: targeting proteolysis for proteome remodeling (ProteoCure)" (CA20113).
Patent holder: Inventor and sole owner of the European patent for industrial application PCT n. PCT/IT2016/000039 entitled "HYBRID PROTEIN FOR THE IDENTIFICATION OF NEDDYLATED SUBSTRATES"; European Patent Application n° 16721959.1 (International Code WO2016132393) issued in 2021. Inventor and sole owner of the American patent for industrial application No.: US 10,302,652 B2, issued on 28-05-2019. Title “HYBRID PROTEIN FOR THE IDENTIFICATION OF NEDDYLATED SUBSTRATES”.
PUBLICATIONS
1) “The Lambda-display technology: a useful tool for the identification of novel Ubiquitin-binding domains”, Santonico, E. Methods in Molecular Biology .2023:2602:163-175. doi: 10.1007/978-1-0716-2859-1_12.
2) Vera F Monteiro-Cardoso, Leila Rochin, Amita Arora, Audrey Houcine, Eeva Jääskeläinen, Anukka M Kivelä, Cécile Sauvanet, Romain Le Bars, Eyra Marien, Jonas Dehairs, Julie Neveu, Naima El Khallouki, Elena Santonico, Johannes V Swinnen, David Tareste, Vesa M Olkkonen, Francesca Giordano. ORP5/8 and MIB/MICOS link ER-mithochondria and intramithochondrial contacts for non-vesicular transport of phosphatidylserine. CELL REPORTS 2022 Sep 20;40(12):111364. doi: 10.1016/j.celrep.2022.111364.
3) RNF11 at the Crossroads of Protein Ubiquitination. Mattioni A, Castagnoli L, Santonico E. BIOMOLECULES. 2020 Nov 11;10(11):1538. doi:10.3390/biom10111538. Mattioni A, Boldt K, Auciello G, Komada M, Rappoport JZ, Ueffing M, Castagnoli L, Cesareni G, Santonico E (2020). Ring Finger Protein 11 (RNF11) acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family. THE FEBS JOURNAL, ISSN: 1742-464X, doi: 10.1111/FEBS.15226
4) Santonico E (2020). Old and New Concepts in Ubiquitin and NEDD8 Recognition. BIOMOLECULES, vol. 10, ISSN: 2218-273X, doi: 10.3390/biom10040566. Castagnoli L, Mandaliti W, Nepravishta R, Valentini E, Mattioni A, Procopio R, Iannuccelli M, Polo S, Paci M, Cesareni G, Santonico E (2019). Selectivity of the CUBAN domain in the recognition of ubiquitin and NEDD8. THE FEBS JOURNAL, vol. 286, p. 653-677, ISSN: 1742-464X, doi: 10.1111/febs.14752
5) Santonico E, Nepravishta R, Mandaliti W, Castagnoli L, Cesareni G, Paci M (2019). CUBAN, a Case Study of Selective Binding: Structural Details of the Discrimination between Ubiquitin and NEDD8. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN: 1661-6596. Nepravishta R, Ferrentino F, Mandaliti W, Mattioni A, Weber J, Polo S, Castagnoli L, Cesareni G, Paci M, Santonico E (2019). CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1. BIOMOLECULES, vol. 9, ISSN: 2218-273X, doi: 10.3390/biom9070284.
