Comparison of Amrubicin, Doxorubicin, Epirubicin, in an Ex Vivo Human Myocardial Strip Model to Evaluate the Accumulation, Metabolism and Bioactivation
Project objectivesThe main aim of the project is to evaluate the pharmacokinetics and cardiotoxic bioactivation of amrubicin in translational models of the human heart in comparison with reference anthracyclines (doxorubicin, epirubicin). |
Start and end date |
| 2009 - 2011 |
Project Manager |
| Giorgio Minotti - Principal Investigator
Emanuela Salvatorelli - co-Principal Investigator Pierantonio Menna - co-Principal Investigator |
Coordinating institution of the project |
| Università Campus Bio-Medico di Roma - UR Pharmaceutical Sciences |
Funding source(s). |
| Celgene and Pharmion LLC Scientific Foundation, Summit, NJ |
