Post-translationally modified insulin as therapeutic target in type 1 diabetes

Project objectives

The project "Oxidative post-translational modifications of insulin as biomarkers of type 1 diabetes prediction, progression, and complications" (OxIDIA) will study and identify, in a large cohort of patients with type 1 diabetes (T1D), new biomarkers for early diagnosis of the disease and for a more in-depth analysis of diabetes progression and complications. Specifically, we will study whether oxidative post-translational modifications of the insulin antibody can predict the development of T1D and associated vascular and bone complications. Furthermore, epigenetic modifications of oxidative stress genes will be evaluated to identify further differences at diagnosis among subjects with T1D. The ultimate goal is to provide new tools for diagnosing the disease to facilitate medical practice and improve the increasingly personalized approach to medicine.

Start and end date

March 2019 - March 2021

Project Manager

Prof. Paolo Pozzilli 

Dr. Rocky Strollo

Coordinating institution of the project

Università Campus Bio-Medico di Roma

Funding source

University Grant - Università Campus Bio-Medico di Roma