Specialized pro-resolving lipid mediators as a new therapeutic strategy in the resolution of the adaptive immune response in multiple sclerosis

Project objectives

The project aims to study the ability of some specialized pro-resolving lipids, such as resolvin D1, resolvin D2 and maresin 1, to restore the altered balance between regulatory T cells and effector T cells obtained from patients with multiple sclerosis, studying the ability of these molecules to modulate both the inflammatory function of these cells involved in the pathogenesis of the disease and their ability to be generated from their stem cell precursors.

Start and end date

2018 - 2020

Project Manager

Dr. Valerio Chiurchiù

Coordinating institution of the project

Università Campus Bio-Medico di Roma

Other Institutions involved

• Santa Lucia Foundation of Rome;
• Tor Vergata Polyclinic in Rome;
• Harvard Medical School;
• University of Amsterdam.

Funding source(s).

Italian Multiple Sclerosis Foundation (FISM)