Study of cross talk between fibroblasts and epithelial cells in the salivary glands of patients with Sjogren's syndrome

Project objectives

Translational study to study the role of fibroblasts in the salivary glands of patients with Sjogren's Syndrome to investigate their role in the recall of lymphocytes, in the formation of ectopic lymphoid structures and their contribution in their maintenance and in the chronicity of the pathology. Furthermore, it aims to evaluate how fibroblasts and epithelial cells can influence each other in creating the niche suitable for the formation of ectopic lymphoid structures in germinal centers through cell co-culture models.

Start and end date

Project Manager

Coordinating institution of the project

Other Institutions involved

• Queen Mary University of London, Center William Harvey Research Institute Charterhouse Square, London, EC1M 6BQ