COMPREHENSIVE GENOMIC PROFILING IN CLINICAL PRACTICE

Project objectives

The development of rapid sequencing techniques, such as next-generation sequencing (NGS), has led to a deeper understanding of cancer and the early stages of personalized oncology. Comprehensive genomic profiling (CGP) is a next-generation sequencing (NGS) approach in which large numbers of DNA fragments are bound to arrays and sequenced in parallel. The work steps are: sample extraction, library preparation, parallel DNA sequencing and data analysis. Thanks to these new technologies, target therapies are becoming increasingly popular through which cancer is treated on the basis of its "molecular identikit", thus creating a "tailor-made" therapy based on the specific characteristics of the patient and the patient. tumor he is fighting. The objective of the study is to verify the Comprehensive Genomic Profiling approach in clinical practice on a population of patients treated at the Campus-Biomedico Polyclinic. In particular, the effectiveness of Comprehensive Genomic Profiling will be evaluated in terms of satisfactory results compared to the case studies analyzed in our laboratory and the ability to highlight target mutations useful for clinical purposes.

Start and end date

Project Manager

Coordinating institution of the project