In situ electrostimulation drives for a regenerative shift in the zone of infarcted myocardium
Project objectives
In vitro electrostimulation of non-stem and stem cells induces myogenic pre-differentiation and may be a powerful tool to generate cells with the capacity to respond to local areas of injury. In this project, the effects of in vivo electrostimulation on infarcted myocardium are evaluated using a miniaturized multi-parameter implantable stimulator in rats. Parameters of electrostimulation are organized to avoid the direct driving or pacing of normal heart rhythm.
Electrical stimuli are delivered for 14 days across the scar site. In situ electrostimulation uses as a cell-free, cytokine-free stimulation system, improves myocardial function and increases angiogenesis through endothelial progenitor cell migration and production of vascular endothelial growth factor (VEGF). In situ electrostimulation may be a new way to stimulate repair of the heart and other organs, as well as to precondition tissue for treatment with cell-based therapies.
Start/End Date
2010 - 2012
Principal Investigator
Prof. Massimo Chello – Coordinator
Host Institution
Campus Bio-Medico University of Rome
Source of funding
Campus Bio-Medico University of Rome
