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Evaluation of the possible role of Upadacitinib in Neuro-Immune axis regulation of pain mediators

Project objectives

Evaluation of the role of the drug Upadacitinib, an inhibitor of the Jak-Stat pathway, in the cellular and molecular mechanisms associated with pain with reference to the possible involvement of the BDNF molecule. In detail, the effect of Upadacitinib will be evaluated on glial cells differentiated from monocytes alone and in coculture with immortalized neuronal cells, macrophages and cells deriving from the synovium of patients suffering from rheumatoid arthritis.

Start and end date

July 2022-December 2024

Project Manager

Prof. Roberto Giacomelli

Coordinating institution of the project

Campus-Biomedical University Polyclinic Foundation

Funding source(s).

Non-profit study funded by Abbvie
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