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Exploratory evaluation of her2 as a potential new therapeutic target in soft tissue sarcomas

Project objectives

  • Evaluation of Her2 expression in cellular models of myxoid liposarcoma, leiomyosarcoma, dedifferentiated liposarcoma, fibrosarcoma and GIST 
  • Analysis of the anti-tumor effect of the Her2 inhibitor, Trastuzumab Deruxtecan, in the same cell lines 
  • Analysis of the anti-tumor effect of the Her2 inhibitor, Trastuzumab Deruxtecan, in chemo-resistant sarcoma cell models

Start and end date

January 2023 – ongoing (December 2025 approximate end date)

Project Manager

Bruno Vincenzi (PI)

Coordinating institution of the project

Università Campus Bio-Medico di Roma

Other Institutions involved

  • University of Barcelona
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