In vitro characterization of MAGL inhibitors

Project Objectives

The project aims at exploring the ability of new chemical entities to inhibit monoacylglycerol lipase (MAGL), a key enzyme that regulates the production of inflammatory mediators that are synthesized from arachidonic acid, and from the endocannabinoid 2-arachidonoylglycerol.

Start/End date

2018 - 2019

Principal Investigator

Prof. Mauro Maccarrone - Coordinator

Host Institution

Campus Bio-Medico University of Rome

Other Institutions involved

  • Università degli Studi di Roma "Tor Vergata"

Source of funding

Hoffmann - La Roche Ltd. (Svizzera)