Type- cannabinoid receptor effect on human colonic motility in patients with slow transit constipation and controls

Project objectives

To study the contractility of smooth muscle cells and colonic tissue strips from patients with slow intestinal transit constipation (STC), correlated with intestinal muscle tissue from control patients. To also investigate the possible role of endocannabinoid receptors in the genesis of altered muscle contractility in patients with STC.

Start and end date

2015 - ongoing

Project Manager

Dr. Annamaria Altomare 

Coordinating institution of the project

Complex Operating Unit of Gastroenterology, Biomedical Campus University of Rome

Other Institutions involved

• General Surgery Unit, Campus Bio-Medico Hospital, Rome
• Biochemistry Unit, Campus Biomedico University of Rome
• Pathological Anatomy Laboratory, Biomedical Campus University of Rome
• Department of Medical and Surgical Sciences, University of Bologna