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Role of Bioactive Lipids in Systemic Lupus Erythematosus

Project Objectives

The main objective of the Project is to identify a possible pathogenetic and biomarker role of some bioactive lipids, such as endocannabinoids and resolvins in Systemic Lupus Erythematosus. In particular, their concentrations are evaluated on patients' plasma and healthy subjects and their synthesis and degradation enzymes as well as their receptors are studied on circulating mononuclear cells. Furthermore, the effects of some of these mediators on cell cultures of patients' immune systems will be evaluated.

Date of the start of the project

2015

Principal Investigators

Prof.ssa Antonella Afeltra, Professore Ordinario

Other Institutions involved

  • Unità di Biochimica e Biologia Molecolare

  • Università Campus Bio-Medico di Roma

  • Unità di Reumatologia

  • Sapienza Università di Roma

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