Apparatus and control method of a robotic manipulator (Italian patent filed, PCT application)
Inventory: F. Cordella, P. Larizza*, C. Lauretti, L. Zollo
Co-ownership with MASMEC SpA (*).
Innovative control strategy for a robotic manipulator cooperating with a human operator, having surgery as main application. The general purpose of the invention is to ensure that the surgeon has continuous control of the force/torque applied to the vertebral pedicles while the robotic arm constrains the position and orientation of the surgical instrument along the axis of movement identified in the pre-operative phase, without losing accuracy in the position along the other directions.
Auxiliary device for the collection and sampling of exhaled air - Pneumopipe (European patent validated in Italy, France, Germany, United Kingdom, Austria and the Netherlands)
Inventory: G. Pennazza, M. Santonico, A. D'Amico, R. Antonelli Incalzi, M. Petriaggi
Portable, compact and easy to use device for non-invasive collection of exhaled air with minimal resistance perceived by the patient. Portable and compact structure, which is very versatile in clinical practice, easy to use for both the doctor and the patient and suitable for use even on bedridden subjects.
Gradual compression biomedical device for the support and optimization of the skin scar (Italian patent, European patent pending)
Inventory: P. Persichetti, S. Filippi, A. Gizzi, G. Marangi, F. Segreto, C. Falcinelli
Customized compression garment to be worn by the patient in the post-operative period, able to reduce tension and traction forces on the wound, preventing hypertrophic, keloid and wound dehiscence scarring and to gradually compress the operated area in such a way as to prevent seroma and hematoma.
Sampling device for food products (Italian patent)
Inventory: G. Pennazza, M. Santonico, A. Zompanti, M. Dachà, A. D'Amico
Sampling device and method for food products, particularly suitable for checking the curing of raw ham. The device allows you to extract a sample of food product in a highly reproducible way.
Device for sampling the ocular surface using imprinting (European patent validated in Italy, France, Germany, United Kingdom)
Inventory: A. Micera*, L. Zollo, B. Balzamino*, I. Ghezzi, R. Sgrulletta
Co-ownership with the GB Bietti Foundation (*).
Device and methodology for the sampling and analysis of superficial layers of the ocular surface, by impression cytology. The device allows safe, accurate and repeatable sampling, highly tolerated by the patient and simplified for the operator.
Device for subcutaneous administration (Italian patent pending)
Inventory: E. Cordelli, L. Francini, S. Manfrini, V. Piemonte, R. Sicily, P. Soda
Device usable for the subcutaneous administration of a medicine and particularly suitable in case of administration of insulin in diabetic subjects. The device is configured to allow adequate and controlled injection into an appropriate body site, also avoiding the onset of lipodystrophies.
Innovative functionalization on liquid phase sensors for the detection of bioactive lipids (Italian patent)
Inventory: M. Maccarrone, G. Pennazza, M. Santonico, S. Grasso, T. Bisogno*
Co-ownership with CNR (*).
Innovative approach of functionalization of chemical sensors for the detection of biochemical substances, in particular bioactive lipids. The innovative electrochemical sensor strategy can be generalized to any sensor working in cyclic voltammetry mode and offers an advantage in enhancing the resolving power of such sensors.
Robotic joint for prosthetic joint (Italian patent, European patent)
Inventory: G. Carpino, L. Bramato, L. Zollo, D. Simonetti
Joint ownership with INAIL.
Innovative prosthetic wrist robotic joint for active prono-supination and passive flexion-extension. The system aims to be used as a stand-alone module, which can be integrated with various hand prostheses; it is also a modular and highly customizable system based on usage requirements.
Bioactive material for cartilage regeneration and process for obtaining the same (Italian patent)
Inventory: M. Centola, V. Denaro, A. Marsano*, I. Martin*, A. Rainer, M. Trombetta, G. Vadala
Co-ownership with Universitatsspital Basel (*).
Porous bioactive material based on hyaluronic acid/fibrin with controlled topical release of an anti-angiogenic drug (bevacizumab) for applications in the regeneration of cartilage and/or nucleus pulposus of the intervertebral disc. The obtained scaffold is able to support neo-cartilage formation when ectopically implanted in vivo. The invention may have a direct repercussion in the clinic, both in the field of technical matrix assisted cell therapy (MACI), and as a construct for regenerative medicine applications.
Porous material for the embedding of cytological preparations, procedure for obtaining the same and its use (Italian patents, European patents, Canada, India, USA filed)
Inventory: A. Crescenzi, M. Trombetta, C. Taffon, A. Rainer, P. Mozetic, M. Costantini, A. Santoro*
Co-ownership with UCS.
Diagnostic srl (*) Chitosan-based porous material that can be used as a support for the inclusion of eukaryotic or prokaryotic cells for the purposes of their processing with histological inclusion techniques. The porous substrate shows a high affinity for the cellular material, which is retained within the mesh of the same, maximizing the yield.
Method of measuring slipping between two surfaces (Italian patent)
Inventory: R. Romeo, L. Zollo, E. Guglielmelli
Joint ownership with INAIL.
Method for the detection of sliding events that may occur during tasks involving the interaction between objects and robotic effectors, such as gripping, manipulation, contact, starting only from the normal force component. The method can be applied to any force sensor and guarantees correct functioning even online.
Method for positioning receptors for sensory stimuli, device obtained by means of said method and equipment comprising said device (Italian patent)
Inventory: C. Oddo, R. Romeo, L. Zollo, L. Beccai, E. Guglielmelli, M. Chiara Carriage
Co-ownership with Scuola Superiore Sant'Anna (*), Italian Institute of Technology (**).
Mathematical method for optimal positioning of tactile sensory units, aimed at recognizing surface roughness during tactile exploration activities. The method makes it possible to obtain the pitch of a texture without requiring a priori information on physical quantities such as, for example, the distance between the sensors themselves.
Method to assist the early diagnosis of pancreatic adenocarcinoma (Italian patent pending, European patent, USA, China pending)
Inventory: Caputo, G. Caracciolo*, R. Coppola, L. Digiacomo*, S. Palchetti*, D. Pozzi*
Co-ownership with La Sapienza University of Rome (*).
Blood test that allows early diagnosis of pancreatic adenocarcinoma. The main difference with respect to the traditional proteomic approach consists in the use of one-dimensional electrophoresis, a low-cost, fast and very widespread experimental technique in clinical laboratories. This method allows early diagnosis of pancreatic adenocarcinoma, in a very insidious tumor since it is often asymptomatic or with non-specific symptoms in the initial stages, and with a very rapid course in the advanced stages.
Method for the determination of a predictive index of the risk of endometrial cancer (Italian patent)
Inventory: R. Angioli, F. Plotti, S. Capriglione, C. Terranova, C. De Cicco, R. Montera, D. Luvero
Risk stratification algorithm (REM-7 Score) for endometrial cancer. The algorithm combines seven variables (body mass index - BMI, duration of endogenous estrogen exposure, concomitant diabetes, age, HE4 dosage, symptoms, ultrasound endometrial thickness) to obtain a risk percentage of malignant endometrial neoplasia (REM).
Statistical methods for the identification of regions of the genome highly representative of the tumor mutational load (Italian patent, European patent pending)
Inventory: P. Manca, A. Napolitano, F. Pantano, D. Santini, G. Tonini
Method that allows the identification of regions of the genome that are most significant for estimating tumor mutational burden (TMB). The method implements the use of machine learning methodsing to resolve the problem. Using this method it is possible to optimize the length of the panel for estimating the TMB, identifying the highly informative regions of the genome, with a reduction in the quantity of genome to be sequenced and, consequently, with a reduction in costs for estimating the TMB in cancer patients. .
Adipose tissue purification technique to obtain a high concentration of adipose stem cells (Italian patent)
Inventory: P. Persichetti, GF Marangi, F. Segreto, F. Pantano, MC Tirindelli, C. Gregorj
Technique for obtaining a purified, autologous and histocompatible biological regenerative matrix, mainly consisting of stem cells. The method has the advantage of being low cost and with minimal manipulation through mechanical procedures; in fact, the use of special equipment or chemical agents is not required, while obtaining a product with a higher concentration of stem cells than other techniques with minimal manipulation.
A tactile sensor device (Italian patent)
Inventory: J. D'Abbraccio*, L. Massari*, CM Oddo*, E. Palermo**, E. Schena, E. Sinibaldi****, G. Terruso***, M. Zaltieri**
Co-ownership with Scuola Superiore Sant'Anna (*), La Sapienza University of Rome (**), Ca' Foscari University of Venice (***), Italian Institute of Technology (****).
Biorobotic sensor, manufacturing process and its application, which results in a sort of artificial skin capable of perceiving the intensity and point of contact of the applied forces, imitating the human sense of touch. Innovative for lightness and adaptability to curved areas, it can cover large surfaces of robotic prostheses and/or collaborative robotic arms.
Accredited spin-off companies
- Biomedical Research in Otolaryngology srl (BRIO)
BRIO produces and distributes innovative biomedical devices for the healthcare sector. In particular, the company distributes SpraySol, an innovative ENT deviceingoiatrics, operable manually, which delivers substances in the form of aerosols.
- COPD media srl (www.bpcomedia.com)
COPD media is an innovative medical device for measuring the patient's state of health capable of detecting the onset of exacerbations, or clinically critical situations, highlighting a symptom with predictive value that the patient is not yet able to perceive, enabling him to contact his doctor for early intervention with respect to a potentially dangerous situation, even before the symptoms appear.
- Brain Innovations srl (www.braininnovations.eu)
Low diagnostic accuracy, symptom monitoring and therapy management are the three main problems of Parkinson's disease today. To solve these problems, Brain Innovations offers an integrated solution, consisting of the following devices:
- Answer to PD: device for the diagnosis of Parkinson's disease;
- Answer to PD: device for monitoring symptoms and as an aid for personalized therapeutic management.
- Epiclick srl (www.epiclick.it)
Epiclick aims to contribute to the prevention of melanoma by exploiting the immediacy of information technology and through the joint use of epiluminescence and the best telematic tools in order to allow remote diagnosis of melanoma, avoiding the long waiting lists of the public service for the patient.
- HEREMOS (https://www.heremos.com/)
Wearable system that allows continuous monitoring of the patient's vital parameters to evaluate, follow and analyze his state of health inside and outside hospital facilities, thus offering the opportunity to shorten the hospitalization period and reduce the readmission rate in hospitals.
- ICAN Robotics srl (www.icanrobotics.com)
It is an innovative start-up active in the field of biomedical robotics and the development of technologies for rehabilitation and physical assistance for patients with neurological, orthopedic or age-related pathologies. ICan Robotics develops innovative and user-friendly products that can be used not only in hospital facilities, but also at home, to benefit the quality of life of patients and their families.
- Move To Zero srl
The company develops and produces innovative services in the field ofingprocess engineering and energy efficiency. Among the activities, a system is being designed for the production of synthetic natural gas starting from CO2 and green hydrogen, generated by electrolysis powered by a solar source.
- WINGED srl
WINGED proposes to create technological platforms for the valorization of agri-food waste, in the logic of the integrated biorefinery for the production of energy, biofuels and organic compounds for fine chemicals and nutraceuticals. The project that gives it its name (WINe GrEen Distillery) concerns the creation of a technological system for the valorisation of waste from wine processing in order to produce products with high added value and green energy.