Apparatus and control method of a robotic manipulator (Italian patent filed, PCT application)

Inventory: F. Cordella, P. Larizza*, C. Lauretti, L. Zollo
Co-ownership with MASMEC SpA (*).

Innovative control strategy for a robotic manipulator cooperating with a human operator, having surgery as main application. The general purpose of the invention is to ensure that the surgeon has continuous control of the force/torque applied to the vertebral pedicles while the robotic arm constrains the position and orientation of the surgical instrument along the axis of movement identified in the pre-operative phase, without losing accuracy in the position along the other directions.

Auxiliary device for the collection and sampling of exhaled air - Pneumopipe (European patent validated in Italy, France, Germany, United Kingdom, Austria and the Netherlands)

Inventory: G. Pennazza, M. Santonico, A. D'Amico, R. Antonelli Incalzi, M. Petriaggi

Portable, compact and easy to use device for non-invasive collection of exhaled air with minimal resistance perceived by the patient. Portable and compact structure, which is very versatile in clinical practice, easy to use for both the doctor and the patient and suitable for use even on bedridden subjects.

Gradual compression biomedical device for the support and optimization of the skin scar (Italian patent, European patent pending)

Inventory: P. Persichetti, S. Filippi, A. Gizzi, G. Marangi, F. Segreto, C. Falcinelli

Customized compression garment to be worn by the patient in the post-operative period, able to reduce tension and traction forces on the wound, preventing hypertrophic, keloid and wound dehiscence scarring and to gradually compress the operated area in such a way as to prevent seroma and hematoma.

Sampling device for food products (Italian patent)

Inventory: G. Pennazza, M. Santonico, A. Zompanti, M. Dachà, A. D'Amico

Sampling device and method for food products, particularly suitable for checking the curing of raw ham. The device allows you to extract a sample of food product in a highly reproducible way.

Device for sampling the ocular surface using imprinting (European patent validated in Italy, France, Germany, United Kingdom)

Inventory: A. Micera*, L. Zollo, B. Balzamino*, I. Ghezzi, R. Sgrulletta

Co-ownership with the GB Bietti Foundation (*).

Device and methodology for the sampling and analysis of superficial layers of the ocular surface, by impression cytology. The device allows safe, accurate and repeatable sampling, highly tolerated by the patient and simplified for the operator.

Device for subcutaneous administration (Italian patent pending)

Inventory: E. Cordelli, L. Francini, S. Manfrini, V. Piemonte, R. Sicily, P. Soda

Device usable for the subcutaneous administration of a medicine and particularly suitable in case of administration of insulin in diabetic subjects. The device is configured to allow adequate and controlled injection into an appropriate body site, also avoiding the onset of lipodystrophies.

Innovative functionalization on liquid phase sensors for the detection of bioactive lipids (Italian patent)

Inventory: M. Maccarrone, G. Pennazza, M. Santonico, S. Grasso, T. Bisogno*

Co-ownership with CNR (*).

Innovative approach of functionalization of chemical sensors for the detection of biochemical substances, in particular bioactive lipids. The innovative electrochemical sensor strategy can be generalized to any sensor working in cyclic voltammetry mode and offers an advantage in enhancing the resolving power of such sensors.

Robotic joint for prosthetic joint (Italian patent, European patent)

Inventory: G. Carpino, L. Bramato, L. Zollo, D. Simonetti

Joint ownership with INAIL.

Innovative prosthetic wrist robotic joint for active prono-supination and passive flexion-extension. The system aims to be used as a stand-alone module, which can be integrated with various hand prostheses; it is also a modular and highly customizable system based on usage requirements.

Bioactive material for cartilage regeneration and process for obtaining the same (Italian patent)

Inventory: M. Centola, V. Denaro, A. Marsano*, I. Martin*, A. Rainer, M. Trombetta, G. Vadala

Co-ownership with Universitatsspital Basel (*).

Porous bioactive material based on hyaluronic acid/fibrin with controlled topical release of an anti-angiogenic drug (bevacizumab) for applications in the regeneration of cartilage and/or nucleus pulposus of the intervertebral disc. The obtained scaffold is able to support neo-cartilage formation when ectopically implanted in vivo. The invention may have a direct repercussion in the clinic, both in the field of technical matrix assisted cell therapy (MACI), and as a construct for regenerative medicine applications.

Porous material for the embedding of cytological preparations, procedure for obtaining the same and its use (Italian patents, European patents, Canada, India, USA filed)

Inventory: A. Crescenzi, M. Trombetta, C. Taffon, A. Rainer, P. Mozetic, M. Costantini, A. Santoro*

Co-ownership with UCS.

Diagnostic srl (*) Chitosan-based porous material that can be used as a support for the inclusion of eukaryotic or prokaryotic cells for the purposes of their processing with histological inclusion techniques. The porous substrate shows a high affinity for the cellular material, which is retained within the mesh of the same, maximizing the yield.

Method of measuring slipping between two surfaces (Italian patent)

Inventory: R. Romeo, L. Zollo, E. Guglielmelli

Joint ownership with INAIL.

Method for the detection of sliding events that may occur during tasks involving the interaction between objects and robotic effectors, such as gripping, manipulation, contact, starting only from the normal force component. The method can be applied to any force sensor and guarantees correct functioning even online.

Method for positioning receptors for sensory stimuli, device obtained by means of said method and equipment comprising said device (Italian patent)

Inventory: C. Oddo, R. Romeo, L. Zollo, L. Beccai, E. Guglielmelli, M. Chiara Carriage

Co-ownership with Scuola Superiore Sant'Anna (*), Italian Institute of Technology (**).

Mathematical method for optimal positioning of tactile sensory units, aimed at recognizing surface roughness during tactile exploration activities. The method makes it possible to obtain the pitch of a texture without requiring a priori information on physical quantities such as, for example, the distance between the sensors themselves.

Method to assist the early diagnosis of pancreatic adenocarcinoma (Italian patent pending, European patent, USA, China pending)

Inventory: Caputo, G. Caracciolo*, R. Coppola, L. Digiacomo*, S. Palchetti*, D. Pozzi*

Co-ownership with La Sapienza University of Rome (*).

Blood test that allows early diagnosis of pancreatic adenocarcinoma. The main difference with respect to the traditional proteomic approach consists in the use of one-dimensional electrophoresis, a low-cost, fast and very widespread experimental technique in clinical laboratories. This method allows early diagnosis of pancreatic adenocarcinoma, in a very insidious tumor since it is often asymptomatic or with non-specific symptoms in the initial stages, and with a very rapid course in the advanced stages.

Method for the determination of a predictive index of the risk of endometrial cancer (Italian patent)

Inventory: R. Angioli, F. Plotti, S. Capriglione, C. Terranova, C. De Cicco, R. Montera, D. Luvero

Risk stratification algorithm (REM-7 Score) for endometrial cancer. The algorithm combines seven variables (body mass index - BMI, duration of endogenous estrogen exposure, concomitant diabetes, age, HE4 dosage, symptoms, ultrasound endometrial thickness) to obtain a risk percentage of malignant endometrial neoplasia (REM).

Statistical methods for the identification of regions of the genome highly representative of the tumor mutational load (Italian patent, European patent pending)

Inventory: P. Manca, A. Napolitano, F. Pantano, D. Santini, G. Tonini

Method that allows the identification of regions of the genome that are most significant for estimating tumor mutational burden (TMB). The method implements the use of machine learning methodsing to resolve the problem. Using this method it is possible to optimize the length of the panel for estimating the TMB, identifying the highly informative regions of the genome, with a reduction in the quantity of genome to be sequenced and, consequently, with a reduction in costs for estimating the TMB in cancer patients. .

Adipose tissue purification technique to obtain a high concentration of adipose stem cells (Italian patent)

Inventory: P. Persichetti, GF Marangi, F. Segreto, F. Pantano, MC Tirindelli, C. Gregorj

Technique for obtaining a purified, autologous and histocompatible biological regenerative matrix, mainly consisting of stem cells. The method has the advantage of being low cost and with minimal manipulation through mechanical procedures; in fact, the use of special equipment or chemical agents is not required, while obtaining a product with a higher concentration of stem cells than other techniques with minimal manipulation.

A tactile sensor device (Italian patent)

Inventory: J. D'Abbraccio*, L. Massari*, CM Oddo*, E. Palermo**, E. Schena, E. Sinibaldi****, G. Terruso***, M. Zaltieri**

Co-ownership with Scuola Superiore Sant'Anna (*), La Sapienza University of Rome (**), Ca' Foscari University of Venice (***), Italian Institute of Technology (****).

Biorobotic sensor, manufacturing process and its application, which results in a sort of artificial skin capable of perceiving the intensity and point of contact of the applied forces, imitating the human sense of touch. Innovative for lightness and adaptability to curved areas, it can cover large surfaces of robotic prostheses and/or collaborative robotic arms.