Research topics

  • Morphological and molecular techniques for studies of prognostic and therapeutic factors in oncology
  • Identification and evaluation of tumor biomarkers on biological tissues by immunohistochemistry, microdissection, gene sequencing and cytogenetic techniques
  • Breast cancer: morphological and molecular characterization of intraepithelial lesions for the development of innovative medical and surgical therapies
  • Pancreatic and ampullary adenocarcinoma: morphological and immunophenotypical features, pathogenesis, molecular basis and therapeutic implications


  • Diagnostic method of pancreatic cancer based on the determination of mutation of the K-RAS gene. A. Onetti Muda, G. Perrone, ITRM20120196A1
  • Porous material for the inclusion of cytologic preparations, process for obtaininging the same and its use. A. Crescenzi, M. Trombetta, C. Taffon, A. Rainer, P. Mozetic, M. Costantini, A. Santoro. EP3534704A1
  • Method for carryinging out in vitro molecular diagnosis of ovarian tumor and kit. A. Scilimati, MG Perrone, S. Ferorelli, A. De Grassi, G. Perrone, F. Zalfa, M. Diaferia, V. Dimiccoli. EP4153784A1

Collaborations with other research centres

  • Dept. of Pathology, Harvard University School of Medicine, Boston, USA
  • Department of Medical Oncology, Hospital Clínic of Barcelona, ​​Translational Genomics and Targeted Therapeutics in Solid Tumors Lab (IDIBAPS)
  •  Department of Experimental Medicine, University of Florence
  • Department of Pharmacy - Pharmaceutical Sciences, University of Bari, A. Moro


The general laboratory of Pathological Anatomy is unique, and activities of both clinical and scientific research interest to carry out

  1. specific research lines of Pathology Unit
  2. collaboration within research lines of Unit

The general laboratory has equipped with a large number of technologically advanced equipment for:

  • histology and cytology
  • histochemical and immunohistochemical stains
  • confocal microscopy
  • molecular biology (mutational analysis, study of gene rearrangements and amplifications, gene expression profile).