Marcello D'Amelio

Professore Ordinario Nuovo regime




Marcello D’Amelio,

Ph.D. in Neuroscience
M.Sc. in Clinical Experimentation


Current position

• Full Professor of Human Physiology, Medical School University Campus-Biomedico, Rome, (I);
• Group leader at the Centro Europeo Ricerca sul Cervello (CERC) – I.R.C.C.S Santa Lucia Foundation IRCCS, Rome (I);
• Member of Scientific Committee, Centre of Molecular Nutrition for Sport (;

Current Research Interests

Analysis of synaptic and neuronal degeneration in rodent models of Alzheimer’s Disease and other neurological disorders; Apoptosis and Autophagy applied to neuroscience field.

Professional Society Membership

• Since 2003 Member of the Italian Society of Biochemistry and Molecular Biology
• Since 2004 Member of the Society of Neuroscience
• Since 2010 Member of the Italian Society of Pharmacology

Editorial activity

• Member of Editorial Board of Neuromolecular Medicine, Scientific Reports;
• Guest Editor of Current Pharmaceutical Design
• Referee of Journal of Alzheimer’s disease, NeuroMolecular Medicine, Journal of Neuroscience Research, World Journal of Pharmacology, European Journal of Neurodegenerative diseases and Cell Death and Disease.

• "Unraveling the mystery of Alzheimer's Disease-related synaptic degeneration" (GR-2011-02351457), supported by Italian Ministry of Health (2014-2017). Role: PI.
• “Preventing and monitoring onset of synaptic degeneration in early AD” (NIRG-11-204588), supported by USA Alzheimer’s Disease Association (2011→2013). Role: PI.
• “Function of reelin in the amygdalo-hippocampal circuit: structural, electrophysiological and behavioral investigations” supported by PRIN (Projects for Research of National Interest) (2011-2013). Role: Head Unit.


Autophagy enhancing compounds, peptides and peptidomimetic compounds for use in the treatment of neuronal diseases - PCT Patent 2012/076555.


Publications (from 2010 to date)

• Cavallucci V, Berretta N, Nobili A, Nisticò R, Mercuri NB, D'Amelio M. Calcineurin inhibition rescues early synaptic plasticity deficits in a mouse model of Alzheimer's disease. Neuromolecular Med. 2013 Sep;15(3):541-8.

• Cervelli M, Bellavia G, D’Amelio M, Cavallucci V, Moreno S, Berger J, Nardacci R, Marcoli M, Maura G, Piacentini M, Amendola R, Cecconi F, Mariottini P. A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury. Plos One 2013 (in press)

• Middei S, Houeland G, Cavallucci V, Ammassari-Teule M, D’Amelio M and Marie H. CREB is necessary for synaptic maintenance and learning- induced changes of the AMPA receptor GluA1 subunit. Hippocampus 2013 (doi: 10.1002/hipo.22108).

• D’Amelio M and Nisticò R. Editorial: Targeting Synaptic Dysfunction and Neural Connectivity in Neurological and Psychiatric disorders. Curr Pharm Des. 2013 (in press).

• Cavallucci V, Ferraina C, D'Amelio M. Key role of mitochondria in Alzheimer's Disease synaptic dysfunction. Curr Pharm Des. 2013 (in press).

• Cavallucci V, D'Amelio M, Cecconi F. Aβ toxicity in Alzheimer's disease. Mol Neurobiol. 2012;45:366-78.

• Fanelli F, Sepe S, D Amelio M, Bernardi C, Cristiano L, Cimini A, Cecconi F, Ceru' MP, Moreno S. Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer's disease. Mol Neurodegener. 2013;8:8.

• Klionsy DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 8, 445-544.

• Viscomi MT, D'Amelio M. The "Janus-faced role" of autophagy in neuronal sickness: focus on neurodegeneration. Mol Neurobiol. 2012; 46:513-21.

• La Rosa LR, Matrone C, Ferraina C, Panico MB, Piccirilli S, Di Certo MG, Strimpakos G, Mercuri NB, Calissano P, D'Amelio M*, Nisticò R*. Age-Related Changes of Hippocampal Synaptic Plasticity in AβPP-Null Mice are Restored by NGF through p75NTR. J Alzheimers Dis. 2012 Sep 6. *Equal Senior Authors.

• D’Amelio M., Sheng M., Cecconi F., Caspase-3 in health and disease of the nervous system. Trends Neurosci. 2012 Jul 13.

• D’Amelio M and Rossini PM. “Brain excitability and connectivity of neuronal assemblies in Alzheimer’s Disease” Prog Neurobiol. 2012 ; 99:42-60.

• Nisticò R, Cavallucci V, Piccinin S, Macrì S, Pignatelli M, Mehdawy B, Blandini F, Laviola G, Lauro D, Mercuri NB, D'Amelio M Insulin Receptor β-Subunit Haploinsufficiency Impairs Hippocampal Late-Phase LTP and Recognition Memory. Neuromolecular Med. 2012;14:262-9.

• Viscomi MT*, D’Amelio M*, Cavallucci V, Latini L, Moreno S., BisicchiaE, Nazio F, Cecconi F. & Marco Molinari M Autophagy activation protects neurons from remote degeneration after acute focal damage, Autophagy. 2012 ;8, 222-235.
* Equal Contributions

• Cavallucci V & D’Amelio M. Matter of life and death: the pharmacological - approaches targeting apoptosis in brain diseases. Current Pharmacology Design, 2011;17, 215-29

• D’Amelio M, Cavallucci V., Middei S., Marchetti C., Pacioni S., Ferri A., Diamantini A., De Zio D., Carrara P., Battistini L., Moreno S., Bacci A., Ammassari-Teule M., Marie H., Cecconi F. Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer’s Disease. Nature Neuroscience, 2011;14:69-76

• Di Bartolomeo S, Corazzari M, Oliverio S,Nazio F, Lisi G, Antonioli M,Paglierini V, Mattoni S, Claudia Fuoco, D’Amelio M, Piacentini M, Cecconi F and Fimia GM The dynamic interaction of Ambra1 with the dynein motor complex regulates mammalian autophagy J Cell Biol. 191:155-68.

• D’Amelio M., Cavallucci V., Cecconi F. Neuronal caspase-3 signalling: not only cell death. Cell Death Differ. 2010;17:1104-14.