Paraskevi Krashia

National University of Athens, Greece B.Sc. 1999-2004 Biology

University College London, UK M.Sc. 2004-2005 Neuroscience

University College London, UK Ph.D. 2005-2009 Pharmacology

POSITIONS

2003-2004: Undergraduate Research Student (B.Sc.)

Department of Biology; National and Kapodistrian University of Athens; Athens, Greece; Tutor: Dr SL. Koussoulakos.

2004-2005: Postgraduate Research Student (M.Sc.)

Department of Anatomy and Developmental Biology; University College London (UCL); London, UK; Tutor: Prof. LG. Sivilotti.

2005-2009: Doctoral Research Scientist (Ph.D.)

Department of Neuroscience, Physiology, Pharmacology; University College London (UCL); London, UK; Tutors: Prof. LG. Sivilotti and Prof. D. Colquhoun.

2010-2011: Postdoctoral Researcher

Department of Neuroscience, Physiology, Pharmacology; University College London (UCL); London, UK; PIs: Prof. Stuart G. Cull-Candy and Prof. Mark Farrant

2011-2012: Postdoctoral Research Fellow

Laboratory of Molecular Biology, Neurobiology Division; Medical Research Council; Cambridge, UK; PI: Dr. Ingo Greger

2012-2015: Postdoctoral Researcher

Laboratory of Experimental Neurology, Santa Lucia Foundation IRCCS; Rome, Italy; PI: Prof. Nicola Biaggio Mercuri

2015-2019: Postdoctoral Researcher

Laboratory of Molecular Neurosciences, Santa Lucia Foundation, IRCCS; Rome, Italy; PI: Prof. Marcello D’Amelio

2019-2020: Postdoctoral Research Fellow (Assegno Di Ricerca)

Unit of Molecular Neurosciences, University Campus Bio-Medico; Rome, Italy; PI: Prof. Marcello D’Amelio

2020-present: Fixed-term University Researcher (RTD-A) – Assistant Professor

Faculty of Sciences and Technologies, University Campus Bio-Medico; Rome, Italy

TEACHING ACTIVITY

2008-2009: Teaching Assistant

Department of Neuroscience, Physiology, Pharmacology; University College London (UCL); UK

Subjects: Neurotoxicology, Neuropharmacology, Molecular Pharmacology

Sept.2009 & 2010: Practical Tutor in Electrophysiology; International Course ‘Microelectrode Techniques for Cell Physiology’ organized by the UK Physiological Society and Marine Biology Association; Plymouth, UK

2019-present: Assistant Professor

Faculty of Sciences and Technologies and Faculty of Medicine and Surgery, University Campus Bio-Medico; Rome, Italy

Subjects: Human Physiology, Biophysics, Neurophysiology Applied to Alimentation

• Possemato E, La Barbera L, Nobili A, Krashia P, D'Amelio M. The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases. Ageing Res Rev. 2023;87:101907.

• Pignataro A, Krashia P, De Introna M, Nobili A, et al. Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism. Transl Psychiatry. 2023;13(1):63.

• La Barbera L, Nobili A, Cauzzi E, Paoletti I, et al. Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer's disease in Tg2576 mice. Mol Neurodegener. 2022;17(1):76.

• Krashia P, Spoleti E, D'Amelio M. The VTA dopaminergic system as diagnostic and therapeutical target for Alzheimer's disease. Front Psychiatry. 2022;13:1039725.

• Spoleti E*, Krashia P*, La Barbera L, Nobili A, et al. Early derailment of firing properties in CA1 pyramidal cells of the ventral hippocampus in an Alzheimer's disease mouse model. Exp Neurol. 2022; 350:113969.

• La Barbera L, Vedele F, Nobili A, Krashia P1, Spoleti E, et al. Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer's Disease. Prog Neurobiol. 2021;202:102031

• Nobili A*, Krashia P*, D'Amelio M. Cisd2: a promising new target in Alzheimer's disease. J Pathol. 2020;251(2):113-116.

• Corsetti V, Borreca A, Latina V, Giacovazzo G, Pignataro A, Krashia P, et al. Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models. Brain Commun. 2020;2(1):fcaa039.

• Romoli M, Krashia P, Sen A, Franciotta D, Gastaldi M, et al. Hippocampal epileptogenesis in autoimmune encephalitis. Ann Clin Transl Neurol. 2019;6(11):2261-2269

• La Barbera L, Vedele F, Nobili A, D'Amelio M, Krashia P1. Neurodevelopmental Disorders: Functional Role of Ambra1 in Autism and Schizophrenia. Mol Neurobiol. 2019;56(10):6716-6724.

• Krashia P, Cordella A, Nobili A, La Barbera L, Federici M, et al. Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease. Nat Commun. 2019;10(1):3945

• Krashia P, Nobili A, D'Amelio M. Unifying Hypothesis of Dopamine Neuron Loss in Neurodegenerative Diseases: Focusing on Alzheimer's Disease. Front Mol Neurosci. 2019; 12:123.

• Nobili A*, Krashia P*1, Cordella A, La Barbera L, et al. Ambra1 Shapes Hippocampal Inhibition/Excitation Balance: Role in Neurodevelopmental Disorders. Mol Neurobiol. 2018; 55(10):7921-7940. (*equal contribution; 1 corresponding author).

• Cordella A*, Krashia P*1, Nobili A, Pignataro A, et al. Dopamine loss alters the hippocampus-nucleus accumbens synaptic transmission in the Tg2576 mouse model of Alzheimer's disease. Neurobiol Dis. 2018; 116:142-154 (*equal contribution; 1 corresponding author).

• Nobili A, Latagliata EC, Viscomi MT, Cavallucci V, Cutuli D, Giacovazzo G, Krashia P, et al. Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease. Nat. Commun. 2017; 8: 14727.

• Krashia P, Martini A, Nobili A, Aversa D, D'Amelio M, Berretta N, Guatteo E, Mercuri NB. On the properties of identified dopaminergic neurons in the mouse substantia nigra and ventral tegmental area. Eur. J. Neurosci. 2017; 45(1): 92-105

• Krashia P, Ledonne A, Nobili A, Cordella A, Errico F, et al. Persistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons. Neuropharmacology 2016; 103: 69-78.

• Squillace M, Dodero L, Federici M, Migliarini S, Errico F, Napolitano F, Krashia P, et al. Dysfunctional dopaminergic neurotransmission in asocial BTBR mice. Transl. Psychiatry 2014; 4: e427.

for Full publication see see:https://www.ncbi.nlm.nih.gov/myncbi/145YRe0Nk-e/bibliography/public/