Giovanna De chiara

DE CHIARA Giovanna

Researcher at the Institute of Translational Pharmacology (IFT), National Research Council (CNR), Rome, Italy

Address work: IFT, CNR, Rome, Italy.

E-mail: [email protected]

EDUCATION

1992 Degree in Chemistry (Sapienza University, Rome, Italy)

1993 Qualification for Chemist Profession

2002 PhD in Neuroscience (Tor Vergata University, Rome, Italy)

2021 National Scientific Qualification to the role of Associate Professor in Microbiology- SSD MED07 (05/28/2021- 05/28/2032)

ACADEMIC AND PROFESSIONAL POSITIONS

2012 to date: Researcher at the Institute of Translational Pharmacology, CNR-Rome, Italy.

2021-2022 and 2022-2023: Adjunct Professor in Virology within the Microbiology course of the International Faculty of Master Degree program in Medicine and Surgery at Campus Biomedico University of Rome

2021 to date: Member of the Scientific Board of PhD in ADVANCES IN INFECTIOUS DISEASES, MICROBIOLOGY, LEGAL MEDICINE AND PUBLIC HEALTH SCIENCES, Sapienza University of Rome, Italy

2005-2012: Staff scientist at ISS, Department of Cell Biology and Neuroscience, Rome, Italy.

2004-2005: Postdoctoral position at the Department of Clinic Physiopathology, School of Medicine, University of Florence, Florence, Italy

2002-2003: Postdoctoral position at the Department of Experimental Medicine and Biochemical Science, School of Medicine, University of Rome “Tor Vergata”, Rome, Italy.

1997-2001: Neuroscience PhD-student at the Department of Experimental Medicine and Biochemical Science, School of Medicine, University of Rome “Tor Vergata”, Rome, Italy.

1994-1997: Research Fellow (MURST fellowship) at the Department of Protein and Peptide Chemistry, Dompè S.p.A. Research Center, L’Aquila, Italy.

1994: Research Fellow (S.T.R.I.D.E. fellowship, CEE) at the Analytical Department of I.S.R.I.M., Terni, Italy.

1992-1994: Visiting researcher at the “Center of Natural Organic Compound Chemistry”, University of Rome “La Sapienza”, Italy.

MAIN RESEARCH INTERESTS

- Neurovirology/ Study of the role of neurotropic viruses in the pathogenesis of neurodegenerative diseases, focusing on herpes simplex virus-1 (HSV-1) possible involvement in Alzheimer’s disease (AD) pathogenesis.

- Virology/ Study of the role of virus/host interactions in controlling the outcomes of viral infections, particularly in neuronal cells: focus on both RNA (e.g., influenza virus) and DNA (e.g., HSV-1) viruses and including the identification of new host-targeted antiviral strategies.

- Neuroscience/ Study of molecular mechanisms underlying neurodegenerative diseases, particularly AD (i.e., amyloid-β signaling, role of DNA damage and alteration of DNA-repair mechanisms in neurodegeneration).

The research group coordinated by Dr De Chiara collaborates with prestigious national and international research teams.

MEMBERSHIP

Italian Society of Microbiology (SIM)

American Society for Neuroscience (SfN)

BIBLIOMETRIC INDEXES

Author of 39 peer-reviewed papers

H Index = 22 (WOS)

Total citations = 1827 (WOS)

Selected 10 relevant publications of the last 10 years (starting from the most recent)

1. De Angelis M, Amatore D, Checconi P, Zevini A, Fraternale A, Magnani M, Hiscott J, De Chiara G, Palamara AT, Nencioni L. Influenza Virus Down-Modulates G6PD Expression and Activity to Induce Oxidative Stress and Promote Its Replication. Front Cell Infect Microbiol. 2022 Jan 6;11:804976. doi: 10.3389/fcimb.2021.804976. PMID: 35071051; PMCID: PMC8770543.

2. Protto V, Marcocci ME, Miteva MT, Piacentini R, Li Puma DD, Grassi C, Palamara AT, De Chiara G. Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies. Curr Opin Pharmacol. 2022 Apr;63:102200. doi: 10.1016/j.coph.2022.102200. Epub 2022 Mar 8. PMID: 35276497.

3. Napoletani G, Protto V, Marcocci ME, Nencioni L, Palamara AT, De Chiara G*. Recurrent Herpes Simplex Virus Type 1 (HSV-1) Infection Modulates Neuronal Aging Marks in In Vitro and In Vivo Models. Int J Mol Sci. 2021. *last author and corresponding author.

4. Li Puma DD, Marcocci ME, Lazzarino G, De Chiara G, Tavazzi B, Palamara AT, Piacentini R, Grassi C. Ca2+ -dependent release of ATP from astrocytes affects herpes simplex virus type 1 infection of neurons. Glia. 2021 Jan;69(1):201-215. doi: 10.1002/glia.23895. Epub 2020 Aug 20. PMID: 32818313.

5. Protto V, Tramutola A, Fabiani M, Marcocci ME, Napoletani G, Iavarone F, Vincenzoni F, Castagnola M, Perluigi M, Di Domenico F, De Chiara G*#, Palamara AT*. Multiple Herpes Simplex Virus-1 (HSV-1) Reactivations Induce Protein Oxidative Damage in Mouse Brain: Novel Mechanisms for Alzheimer's Disease Progression. Microorganisms. 2020 Jun 29;8(7):972. doi: 10.3390/microorganisms8070972. PMID: 32610629; PMCID: PMC7409037. * last authors, # corresponding author.

6. Prezioso C, Marcocci ME, Palamara AT, De Chiara G, Pietropaolo V. The "Three Italy" of the COVID-19 epidemic and the possible involvement of SARS-CoV-2 in triggering complications other than pneumonia. J Neurovirol. 2020 Jun;26(3):311-323. doi: 10.1007/s13365-020-00862-z. Epub 2020 Jun 16. PMID: 32548750; PMCID: PMC7297137.

7. Marcocci ME, Napoletani G, Protto V, Kolesova O, Piacentini R, Li Puma DD, Lomonte P, Grassi C, Palamara AT, De Chiara G. Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection. Trends Microbiol. 2020 Oct;28(10):808-820. doi: 10.1016/j.tim.2020.03.003. Epub 2020 May 5. PMID: 32386801.

8. De Chiara G*, Piacentini R, Fabiani M, Mastrodonato A, Marcocci ME, Limongi D, Napoletani G, Protto V, Coluccio P, Celestino I, Li Puma DD, Grassi C, Palamara AT. Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice. PLoS Pathog. 2019 Mar 14;15(3):e1007617. doi: 10.1371/journal.ppat.1007617. PMID: 30870531; PMCID: PMC6417650. *first author and corresponding author.

9. Li Puma DD, Piacentini R, Leone L, Gironi K, Marcocci ME, De Chiara G, Palamara AT, Grassi C. Herpes Simplex Virus Type-1 Infection Impairs Adult Hippocampal Neurogenesis via Amyloid-β Protein Accumulation. Stem Cells. 2019 Nov;37(11):1467-1480. doi: 10.1002/stem.3072. Epub 2019 Aug 22. PMID: 31381841.

10. De Chiara G*, Racaniello M, Mollinari C, Marcocci ME, Aversa G, Cardinale A, Giovanetti A, Garaci E, Palamara AT, Merlo D*. Herpes Simplex Virus-Type1 (HSV-1) Impairs DNA Repair in Cortical Neurons. Front Aging Neurosci. 2016 Oct 18;8:242. doi: 10.3389/fnagi.2016.00242. PMID: 27803664; PMCID: PMC5067485* corresponding authors