Alessandro Leuti

Alessandro Leuti

PhD in Food Sciences and Human Nutrition

MSc in Biology and Human Evolution

Current position

- Research Fellow, Biochemistry and Molecular Biology Unit, Department of Medicine, Campus Bio-Medico University of Rome

- Guest researcher, Lipid Neurochemistry Unit, European Center for Brain Research (CERC), IRCCS Santa Lucia Foundation

- Adjunct Professor of Molecular Biology, Human Nutrition Sciences Bachelor’s Degree, Campus Bio-Medico University of Rome

Curator of Scientific updates section for the Italian Association of Neuroimmunology (AINI)

Scientific Society Memberships

Member of the Italian Association of Neuroimmunology (AINI)

Member of the Italian Society of Immunology, Clinical Immunology and Allergology (SIICA)

Krashia P*, Cordella A*, Nobili A*, La Barbera L, Federici M, Leuti A, Campanelli F, Natale G, Marino G, Calabrese V, Vedele F, Ghiglieri V, Picconi B, Di Lazzaro G, Schirinzi T, Sancesario G, Casadei N, Riess O, Bernardini S, Pisani A, Calabresi P, Viscomi MT, Serhan CN, Chiurchiù V, D'Amelio M, Mercuri NB. Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease. Nat Commun. 2019 Sep 2;10(1):3945

Piscitelli F, Coccurello R, Totaro A, Leuti A, Giacovazzo G, Verde R, Rossi E, Podaliri Vulpiani M, Ferri N, Giacominelli Stuffler R, Di Marzo V, Oddi S, Bisogno T, Maccarrone M. Targeted Lipidomics Investigation of N‐acylethanolamines in a Transgenic Mouse Model of AD: A Longitudinal Study. Eur J Lipid Sci Technol. 2019 Jul.

Leuti A, Maccarrone M, Chiurchiù V. Proresolving Lipid Mediators: Endogenous Modulators of Oxidative Stress. Oxid Med Cell Longev. 2019 Jun 18;2019:8107265.

Gentile A et al. Peripheral T cells from multiple sclerosis patients trigger synaptotoxic alterations in central neurons. Neuropathol Appl Neurobiol. 2019 May 24.

Chiurchiù V, Leuti A, Saracini S, Fontana D, Finamore P, Giua R, Padovini L, Antonelli Incalzi R, Maccarrone M. Resolution of inflammation is altered in chronic heart failure and entails a dysfunctional responsiveness of T lymphocytes. FASEB J. 2019 Jan;33(1):909-916.

Chiurchiù V*, Leuti A*, Smoum R, Mechoulam R, Maccarrone M. Bioactive lipids ALIAmides differentially modulate inflammatory responses of distinct subsets of primary human T lymphocytes. FASEB J. 2018 Jun 7:fj201800107R.

Maccarrone M, Totaro A, Leuti A, Giacovazzo G, Scipioni L, Mango D, Coccurello R, Nisticò R, Oddi S. Early Alteration of Distribution and Activity of Hippocampal Type-1 Cannabinoid Receptor in Alzheimer's Disease-like Mice Overexpressing the Human Mutant Amyloid Precursor Pharmacol Res. 2018 Apr;130:366-373.

Chiurchiù V*, Leuti A*, Maccarrone M*. Bioactive Lipids and Chronic Inflammation: Managing the Fire Within.Front Immunol. 2018 Jan 29;9:38.

Bisicchia E et al. Resolvin D1 Halts Remote Neuroinflammation and Improves Functional Recovery after Focal Brain Damage Via ALX/FPR2 Receptor-Regulated MicroRNAs. Mol Neurobiol. 2018 Aug;55(8):6894-6905.

Marrone MC, Morabito A, Giustizieri M, Chiurchiù V, Leuti A, Mattioli M, Marinelli S, Riganti L, Lombardi M, Murana E, Totaro A, Piomelli D, Ragozzino D, Oddi S, Maccarrone M, Verderio C, Marinelli S. TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice. Nat Commun. 2017 May 10;8:15292.

Chiurchiù V, Leuti A, Cencioni MT, Albanese M, De Bardi M, Bisogno T, Centonze D, Battistini L, Maccarrone M. Modulation of monocytes by bioactive lipid anandamide in multiple sclerosis involves distinct Toll-like receptors. Pharmacol Res. 2016 Nov;113(Pt A):313-319.

Chiurchiù V et al. Anandamide Suppresses Proinflammatory T Cell Responses In Vitro through Type-1 Cannabinoid Receptor-Mediated mTOR Inhibition in Human Keratinocytes. J Immunol. 2016 Nov 1;197(9):3545-3553.

Chiurchiù V, Leuti A, Dalli J, Jacobsson A, Battistini L, Maccarrone M, Serhan CN. Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses. Sci Transl Med. 2016 Aug 24;8(353):353ra111.

Chiurchiù V, Leuti A, Maccarrone M. Cannabinoid Signaling and Neuroinflammatory Diseases: A Melting pot for the Regulation of Brain Immune Responses. J Neuroimmune Pharmacol. 2015 Jun;10(2):268-80.

Leuti A* and Laurenti D* et al. Phosphodiesterase 10A (PDE10A) localization in the R6/2 mouse model of Huntington's disease. Neurobiol Dis. 2013 Apr;52:104-16.

Fusco FR et al. Changes in the expression of extracellular regulated kinase (ERK 1/2) in the R6/2 mouse model of Huntington's disease after phosphodiesterase IV inhibition. Neurobiol Dis. 2012 Apr;46(1):225-33.