Giovanni Fasciglione
Biography
Personal details
Surname Name Fasciglio Giovanni
Date and Place of Birth 13/03/1965 Taranto (Ta)
Italian citizenship
Home address Via Don Bosco 65 00044 Frascati (Rm)
Education (documented university education)
Years Profile of completed Education, Institution, Place
1978- 1983 European Baccalaureate, Science, Mathematics and Latin section (67/100). Brussels (Belgium)
1983- 1988 Degree in Biological Sciences (110/110 cum laude) at the University of Rome "La Sapienza". Rome
Post-graduate training (documented)
Year(s) Training profile completed, Duration, Institution, Place
1991 Advanced course in molecular biology, called GCI at Menarini Sud, Pomezia (Rm) "Chimeric antibodies".
1991-1995 PhD in biochemistry at the University of Rome "Tor Vergata". Rome
1996 Annual scholarship awarded by the “Enrico and Enrica Sovena” foundation
1997 Annual scholarship awarded by the “Enrico and Enrica Sovena” foundation
Qualifications (scientific/academic/other) and qualifications held (documented)
Title Year Institution of emanation, Place
PhD in Biochemistry 1995 University of Rome "La Sapienza". Rome
Curriculum
Work experiences
Year(s) Function, Type of work, Institution-Structure, Place
1995 Biomedical consultancy contract: preparation of cell cultures, cell activation with mitogens, seriological dosage using immunoenzymatic methods. Aeronautical Medicine Department, Studies, Research and Experiments Area Division, Pratica di Mare Airport
1998/99 Collaborator in the laboratories of the Department of Experimental Medicine and Biochemical Sciences Faculty of Medicine Univ. "Tor Vergata", Rome, for the chair of General Chemistry of prof. M. Coletta
2000 to present Technical Assistant (VI qf) at the University of Rome "Tor Vergata" Faculty of Medicine, for the chair of General Chemistry of prof. M. Coletta.
Educational experiences
Year(s) Discipline taught, Course of…, Typology (lectures/practices), Institution, Place
1991/92 As part of the Chemistry course for the Medicine and Surgery degree course at the Catholic University of the Sacred Heart, he carried out theoretical-practical exercises and was a member of the examination commissions.
From a.y. 94/95 to date he He carries out theoretical-practical lessons and is part of the examination commissions for the Chemistry courses Gen. Prop. Bioch. of the Degree course in Medicine and Surgery and General Chemistry for the Degree course in Dentistry for the Faculty of Medicine Univ. "Tor Vergata".
From the 2012/2013 academic year to date Teacher for the Chemistry course Gen. Prop. Bioch. of the degree course in Medicine and Surgery and General Chemistry for the Faculty of Medicine University "Our Lady of Good Counsel" of Tirana, Albania.
From the 2017 academic year to date Teacher for the Chemistry course Gen. Prop. Bioch. of the Degree course in Dietetics for the Faculty of Medicine Univ. "Tor Vergata".
AY 2019/2020 Lecturer for the course of Biochemistry and Molecular Biology of the Degree course in Dentistry and Dental Prosthesis for the Faculty of Medicine "Albanian University" of Tirana, Albania.
From the 2021/2022 academic year to date Lecturer in charge of the "Single Courses" for the subject Chemistry Gen. Prop. Bioch. of the degree course in Medicine and Surgery for the Faculty of Medicine Univ. "Tor Vergata".
Other functions performed
Year(s) Function/Type of commitment, Institution-Structure, Place
1993
Lecturer at the practical course: "Monoclonal antibodies in agro-food diagnostics" organized by the CNR at the University of Tuscia in Viterbo as part of the Finalized Project RAISA.
PUBLICATIONS
Last 10 Publications
20. Magda Joy, Giovanni Francesco Fasciglione, Susanna Monaco, Riccardo Iundusi, Diego Sbardella, Stefano Marini, Umberto Tarantino, Massimo Coletta. (2010) pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain. European Journal of Biochemistry 15(8):1219-32.
21. Diego Sbardella, Giovanni Francesco Fasciglione, Magda Gioia, Chiara Ciaccio, Grazia Raffaella Tundo, Stefano Marini, Massimo Coletta. (2011) Human matrix metalloproteinases: an ubiquitous class of enzymes involved in several pathological processes. Molecular Aspects of Medicine 33(2):119-208.
22. Giovanni Francesco Fasciglione, Magda Gioia, Hiroki Tsukada, Jian Liang, Riccardo Iundusi, Umberto Tarantino, Massimo Coletta, Tayebeh Pourmotabbed, Stefano Marini. (2012) The collagenolytic action of MMP-1 is regulated by the interaction between the catalytic domain and the hinge region. European Journal of Biochemistry 17(4):663-72.
23. Diego Sbardella, Grazia R Tundo, Giovanni Francesco Fasciglione, Magda Gioia, Salvatore Bisicchia, Elena Gasbarra, Ernesto Ippolito, Umberto Tarantino, Massimo Coletta, Stefano Marini: Role Of Metalloproteinases In Tendon Pathophysiology.. Mini Reviews in Medicinal Chemistry 11/2014; 14(12)., DOI:10.2174/1389557514666141106132411
24. Magda Gioia, Giulia Vindigni, Barbara Testa, Sofia Raniolo, Giovanni Francesco Fasciglione, Massimiliano Coletta, Silvia Biocca: Membrane Cholesterol Modulates LOX-1 Shedding in Endothelial Cells. PLoS ONE 10/2015; 10(10):e0141270., DOI:10.1371/journal.pone.0141270
25. Magda Joy, Luigi Tom, Diego Sbardella, Chiara Ciaccio, Grace Raffaella Tundo, Alessandra Di Masi, Giovanni Francesco Fasciglione, Stefano Marini, Paola Cozza, Paolo Ascenzi, Massimo Coletta: Enzyme catalysis: the case of the prostate-specific antigen. Lincei reports. Physical and Natural Sciences 02/2017;, DOI:10.1007/s12210-017-0602-6
26. The enzymatic processing of α-dystroglycan by MMP-2 is controlled by two anchoring sites distinct from the active site.
Gioia M, Fasciglione GF, Sbardella D, Sciandra F, Casella M, Camerini S, Crescenzi M, Gori A, Tarantino U, Cozza P, Brancaccio A, Coletta M, Bozzi M.
PLoS One. 2018 Feb 15; 13 (2): e0192651. doi: 10.1371 / journal.pone.0192651. eCollection 2018.
27. Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors.
Mangiatordi GF, Guzzo T, Rossano EC, Trisciuzzi D, Alberga D, Fasciglione G, Coletta M, Topai A, Nicolotti O.
ChemMedChem. 2018 Jul 6;13(13):1343-1352. doi: 10.1002/cmdc.201800237. Epub 2018 Jun 12.
28. Gelatinolytic activity in gingival crevicular fluid and saliva of growing patients with Marfan syndrome: a case-control study.
Laganà G, Fasciglione GF, Biondi A, Coletta M, Ruvolo G and Cozza P.
BMC OralHealth. 2019 19:161 DOI: 10.1186/s12903-019-0854-x
29. Gioia M, Ciaccio C, Calligari P, De Simone G, Sbardella D, Tundo G, Fasciglione GF, Di Masi A, Di Pierro D, Bocedi A, Ascenzi P, Coletta M. Role of proteolytic enzymes in the COVID-19 infection and promising therapeutic approaches. Biochem Pharmacol. 2020 Dec;182:114225. doi: 10.1016/j.bcp.2020.114225. Epub 2020 Sep 19. PMID: 32956643; PMC ID: PMC7501082.
30. Alloisio G, Ciaccio C, Fasciglione GF, Tarantino U, Marini S, Coletta M, Gioia M. Effects of Extracellular Osteoanabolic Agents on the Endogenous Response of Osteoblastic Cells. Cells. 2021 Sep 10;10(9):2383. doi:10.3390/cells10092383. PMID: 34572032; PMC ID: PMC8471159.
