Project Fondazione Roma, 2009 Call "Intracellular Protein-Protein Interactions regulating viral replication as targets for novel antiviral strategies"
Project Objectives
The project aims at discovering new compounds for the control of viral infections by manipulating intracellular protein-protein interactions (PPI). HIV-1 and influenza A virus (IAV) were used as paradigms for chronic and acute viral infections, respectively.
For HIV infection, the proposed strategy was to encourage the virus to escape from latency in order to deplete its reservoirs and kill infected cells.
In the case of influenza, the proposed strategy aims at inhibiting viral replication and limit the inflammation elicited by the virus via interaction with specific intracellular redox-sensitive mechanisms.
The Università Campus Bio-Medico di Roma research group has characterized the epigenetic and gene expression changes in HDACi treated or untreated cells, infected and uninfected, and the comparative modulation of the expression of inflammation-related genes in acute infection.
Start/End Date
June 1, 2009 - May 31, 2011
Principal Investigator
Prof. Vito Michele Fazio
Host Institution
Università di Roma “Tor Vergata”
Other Institutions involved
- Università di Roma “Tor Vergata”
- Università di Roma “La Sapienza”
Source of funding
Fondazione Roma