Rome Foundation Project, Call 2009 "Intracellular Protein-Protein Interactions regulating viral replication as targets for novel antiviral strategies"
Project objectivesThe project aims to discover novel compounds by manipulating cellular protein-protein interactions (PPIs) to control viral infections. HIV-1 and influenza A virus (IAV) have been used as paradigms for chronic and acute viral infections, respectively. In HIV infection, the proposed strategy consisted of inducing viral escape from latency to eliminate reservoirs and kill infected cells. In influenza, the proposed strategy aims to inhibit viral replication and limit virus-induced inflammation through interaction with specific redox-sensitive intracellular mechanisms. The groupUniversità Campus Bio-Medico di Roma characterized epigenetic and gene expression changes in HDACi-treated and untreated, infected and uninfected cells, and the comparative modulation of the expression of inflammation-related genes in the mechanism of acute infection. |
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Start and end date |
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01/06/2009 - 31/05/2011 |
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Project Manager |
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Prof. Vito Michele Fazio - Scientific manager |
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Coordinating institution of the project |
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University of Rome "Tor Vergata" |
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Other Institutions involved |
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Funding source(s). |
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Rome Foundation |
