Project objectives
The study aims to evaluate the toxicities reported during RS (radiosurgery) or HFSRT (hypofractionated stereotactic radiotherapy) in patients suffering from brain metastases from NSCLC during immunotherapy (Safety), with particular reference to the rate of symptomatic radionecrosis and intralesional hemorrhage. Other primary objectives of the study are Feasibility and intracranial disease control, both local (site of radiotherapy treatment) and distant (intracranial, but distant from the site of disease treated with stereotactic radiotherapy). Secondary objectives concern evaluation
of the quality of life of the patients under study (Quality Of Life, QoL). |
- National CANCER Institute-IRCCS--G. Pascale Foundation-Naples
- Department of Radiotherapy and Radiosurgery Humanitas Research Hospital, Rozzano (MI)
- Radiation Oncology Center. S. Maria Hospital, Terni
- Cyberknife Italian Diagnostic Center Milan
- Radiotherapy Unit, Department of Oncology, University of Turin, Turin
- Uoc radiotherapy Aou sant'Andrea faculty of medicine and psychology at Sapienza University, Rome
- Uo radiotherapy Foundation IRCCS neurological institute Carlo Besta, Milan
- Department of advanced radiation oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona
- Radiotherapy Unit, Department of Oncology and Hematology, University Hospital of Modena, Modena
- Oncological Radiotherapy Campus Biomedico Rome
- ASST Spedali Civili di Brescia and University of Brescia, Radiotherapy Oncology Unit
- Radiotherapy oncology, Maggiore della Carità University Hospital, Novara
- Oncological Radiotherapy, AUSL-IRCCS Reggio Emilia
- Oncology radiotherapy, Pisa University Hospital, Pisa
- UOC Radiotherapy Oncology, SS Annunziata Clinical Hospital, G.D'Annunzio University, Chieti
- Radiotherapy oncology ASOSCroce and Carle, Cuneo
- Division of Radiation Oncology, Europe Institute of Oncoology, Milan
- Department of medical area, University of Udine, ASUIUD, Udine
- UOC Radiotherapy Carrara (MS), Italy
- SC Radiotherapy Santa Maria Annunziata Hospital, Bagno a Ripoli (Fi)
- Oncological Radiotherapy ASO SS Antonio Biagio and Cesare Arrigo, Alessandria
- UOC Radiotherapy IOV-IRCCS Padua
- UOC Radiotherapy, Ospedale del Mare, Naples
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