Director: Prof. Giuseppe Perrone

Specialist profile

The specialist in Pathology must have acquired theoretical, scientific, and professional knowledge in the field of systematic anatomical pathology, particularly in histopathological and cytopathological diagnostics, intraoperative and ultrastructural diagnostics, and biomolecular characterization of tissue and organ lesions and the entire organism, aimed at their diagnosis. This knowledge is also useful for prognostic and therapeutic guidance, and for the epicritical evaluation of the diagnosis and its related anatomical and clinical findings.

To this end, the specialist in pathological anatomy must acquire the necessary skills in the application and diagnostic interpretation in human pathology of anatomical, histological, cytological, histochemical, immunohistochemical, ultrastructural and molecular biology methods, as well as skills in the use of methods related to quality and quantitative assessments.

Why choose the School of Specialization in Pathological Anatomy UCBM

The Specialization Schools ofUniversità Campus Bio-Medico di Roma They are not subject to a minimum number of residents per year and therefore do not need to form consortiums with other universities. This ensures that the training program will be conducted primarily at the School's headquarters, at the Fondazione Policlinico Universitario Campus Bio-Medico.

The limited number of residents allows for a thorough customization of the training program, also based on individual skills and aptitudes. A high staff-to-resident ratio is guaranteed, allowing for dedicated and personalized tutoring.

Starting in the first year of specialization, trainees complete four-month rotations in all areas of specialized pathology (e.g., gastrointestinal pathology, thoracic pathology, urological pathology, breast pathology, hematopathology, gynecological pathology, skin pathology, etc.), working alongside specialist pathologists with extensive experience in specific areas of pathology. This structured and consolidated training approach allows for periods of full immersion in all specialist areas of the discipline.

During the period of support from the reference tutor, the trainees participate in the weekly Multidisciplinary Meetings so as to increase the clinical knowledge connected to Pathological Anatomy.

The School is integrated with a large Training Network: five public and private hospitals with high-volume affiliations to ensure attendance at local hospital services. Attendance at the training network prepares residents for diagnostic work in non-university facilities that may offer them future career opportunities. The hospitals in the Training Network are primarily located in the city of Rome, allowing for effective attendance and use.

Pursuant to the Calabria Decree, eligible Pathology residents have been given the opportunity to obtain an employment contract at our Pathology Unit. Currently, these colleagues, under the supervision of the Director, have the opportunity to gain firsthand experience practicing their profession by actively participating in the Department's activities. Working independently in the protected environment of the Specialization School is certainly the best training ground for professional growth, ensuring the creation of a competitive professional resume.

The numbers of the Complex Operative Unit of Pathological Anatomy (School Headquarters)

  • 80.000 histological, cytological, molecular samples per year, autopsy findings and consultancy.
  • Complete digitalization of the diagnostic process with high-level computerization of the Service and integration with the Electronic Medical Record.
  • Personnel: 11 specialist pathologists, 4 molecular biologists, 11 biomedical laboratory technicians, 3 administrative staff.
  • 8 Specialists
  • Adequate spaces that allow for the assignment of workstations with computers and professional microscopes for each student.
  • Microscope with didactic bridge for all tutors, for visualization of microscope specimens in tandem with the resident.
  • Multiple microscope and digital room for collegial discussion of teaching cases.
  • Laboratory equipped with latest generation technologies for routine diagnostic activity.
  • Predictive Molecular Diagnostics Unit, equipped with the most modern Next Generation Sequencing (NGS) technologies, gene expression profiling, and FISH analyses for the molecular characterization of neoplastic diseases.
  • Electron Microscopy service dedicated to non-neoplastic renal disease.
  • Digital Pathology service for remote case sharing.
  • Modern sector room.

Educational and scientific project

Each year, a series of seminars and lectures by national experts is scheduled, focusing on specific topics in Pathological Anatomical and Predictive Molecular Pathology. These lectures provide the fundamental knowledge needed to complete the training, which will advance the discipline's future. The Specialization School is connected to the National Network of Pathological Anatomical Schools, allowing attendance at courses organized by the Scientific Society.

The School encourages and promotes scientific activity. Residents are involved in basic and translational scientific projects, allowing them to engage in research activities specific to the Department of Pathological Anatomy at Campus Bio-Medico University. This aspect, considered fundamental to the training of the modern pathologist, allows them to complete their professional curriculum through the publication of scientific research.

Participation of postgraduates in National Scientific Congresses is encouraged, also by presenting the results of their research.

Post-graduate students can carry out tutoring activities for Campus Bio-Medico University Medicine Students, both for teaching internships and as co-supervisors for degree theses.

The School allows you to develop specific training projects also through contact with various European Centers for possible training periods abroad.

Research products of our trainees in the last three years

  • Capozzi A, Rossi SM, Sabarese G, Germani M, Gullotta G, Sfregola S, Perrone G. Oncotype DX in clinical practice: impact on treatment decisions and healthcare system economy. Pathological. 2025; In press.
  • Cea L, Santucci D, Bernetti C, Nibid L, Tomarchio V, Bruno A, Beomonte Zobel B, Grasso RF, Faiella E. A Rare Case of Hodgkin Lymphoma With Isolated Epitrochlear Lymphadenopathy. Our Experience and Main Differential Diagnosis. Case Rep Med. 2025 Jul 10;2025:5548125. doi: 10.1155/carm/5548125.
  • Capozzi A, Jansen FA, Smetsers SE, Bakhuizen JJ, Hiemcke-Jiwa LS, Kranendonk MEG, Flucke U, Alaggio R, de Krijger RR. The Histological Spectrum of DICER1-Associated Neoplasms. Pediatr Dev Pathol. 2025 Jul-Aug;28(4):231-243. doi: 10.1177/10935266251329752.
  • Bishop M, Raspollini MR, Nibid L, Castiglione F, Nardi E, de Biase D, Massari F, Giunchi F, Pepe F, Troncone G, Malapelle U, Carosi M, Casini B, Melucci E, Fassan M, Toffolatti L, Guerini-Rocco E, Conversano F, Rappa A, Tommasi S, Coppola CA, Zeppa P, Caputo A, Gaeta S, Pagni F, Seminati D, Vecchione A, Scarpino S, Righi D, Taffon C, Prata F, Perrone G. Storage Time and DNA Quality Determine BRCA1/2 Sequencing Success in Prostate Cancer: A Multicentre Analysis with Therapeutic Implications. Cancers (Basel). 2025 May 20;17(10):1705. doi: 10.3390/cancers17101705.
  • Carbone L, Incognito GG, Incognito D, Nibid L, Caruso G, Berretta M, Taffon C, Palumbo M, Perrone G, Roviello F, Marrelli D. Clinical implications of epithelial-to-mesenchymal transition in cancers which potentially spread to peritoneum. Clin Transl Oncol. 2025 Jul;27(7):2838-2851. doi: 10.1007/s12094-024-03837-2.
  • Rakaee M, Tafavvoghi M, Ricciuti B, Alessi JV, Cortellini A, Citarella F, Nibid L, Perrone G, Adib E, Fulgenzi CAM, Hidalgo Filho CM, Di Federico A, Jabar F, Hashemi S, Houda I, Richardsen E, Rasmussen Busund LT, Donnem T, Bahce I, Pinato DJ, Helland Å, Sholl LM, Awad MM, Kwiatkowski DJ. Deep Learning Model for Predicting Immunotherapy Response in Advanced Non-Small Cell Lung Cancer. JAMA Oncol. 2025 Feb 1;11(2):109-118. doi: 10.1001/jamaoncol.2024.5356.
  • Venetis K, Cursano G, Scafetta R, Giachetti PPMB, Concardi A, De Camilli E, D'Ercole M, Mane E, Frascarelli C, Marra A, Gandini S, Pepe F, Scagnoli S, Rossi SM, Troiano R, Speziale E, De Angelis C, Troncone G, Malapelle U, Perrone G, Botticelli A, Viale G, Curigliano G, Guerini Rocco E, Criscitiello C, Fusco N. ESR1 testing on FFPE samples from metastatic lesions in HR + /HER2- breast cancer after progression on CDK4/6 inhibitor therapy. Breast Cancer Res. 2025 May 14;27(1):79. doi: 10.1186/s13058-025-02020-x.
  • Pantano F, Simonetti S, Iuliani M, Guillen MJ, Cuevas C, Aviles P, Cavaliere S, Napolitano A, Cortellini A, Mazzocca A, Nibid L, Sabarese G, Perrone G, Gambarotti M, Righi A, Palmerini E, Stacchiotti S, Barisella M, Gronchi A, Valeri S, Sbaraglia M, Dei Tos AP, Tonini G, Vincenzi B. Sp-bromobenzyl-glutathione cyclopentyl diester (BBGC) as a novel therapeutic strategy to enhance trabectedin anti-tumor effect in soft tissue sarcoma preclinical models. Oncogene. 2024 Sep;43(40):2986–2994. doi: 10.1038/s41388-024-03143-9. Epub 2024 Aug 28.
  • Fusco N, Ivanova M, Frascarelli C, Criscitiello C, Cerbelli B, Pignataro MG, Pernazza A, Sajjadi E, Venetis K, Cursano G, Pagni F, Di Bella C, Accardo M, Amato M, Amico P, Bartoli C, Bogina G, Bortesi L, Boldorini R, Bruno S, Cabibi D, Caruana P, Dainese E, De Camilli E, Dell'Anna V, Duda L, Emmanuele C, Fanelli GN, Fernandes B, Ferrara G, Gnetti L, Gurrera A, Leone G, Lucci R, Mancini C, Marangi G, Mastropasqua MG, Nibid L, Orrù S, Pastena M, Peresi M, Perracchio L, Santoro A, Vezzosi V, Zambelli C, Zuccalà V, Rizzo A, Costarelli L, Pietribiasi F, Santinelli A, Scatena C, Curigliano G, Guerini-Rocco E, Martini M, Graziano P, Castellano I, d'Amati G. Advancing the PD-L1 CPS test in metastatic TNBC: Insights from pathologists and findings from a nationwide survey. Crit Rev Oncol Hematol. 2023 Oct;190:104103. doi: 10.1016/j.critrevonc.2023.104103.
  • Bearzi P, Trunfio F, Coppola R, Currado D, Conforti C, Zanframundo S, Nibid L, Donati M, Panasiti V, Navarini L, Giacomelli R. Necrobiosis-Lipoidica-Like Skin Lesions in a Patient with Non-Systemic Sarcoidosis. Dermatol Pract Concept. 2023 Jul 1;13(3):e2023183. doi: 10.5826/dpc.1303a183.
  • Bianchi A, Baldi A, Farabini A, Nibid L, Roberti V, Pellacani G, Kazakov DV, Donati M. Dermatoscopic, Histological and Confocal Microscopic Analysis of a Kissing Nevus of the Penis. Dermatopathology (Basel). 2023 May 31;10(2):147-152. doi: 10.3390/dermatopathology10020022.
  • Nibid L, Sabarese G, Andreotti L, Canalis B, Righi D, Longo F, Grazi M, Crucitti P, Perrone G. RNA-Seq Analysis in Non-Small Cell Lung Cancer: What Is the Best Sample from Clinical Practice? J Pers Med. 2024 Aug 11;14(8):851. doi: 10.3390/jpm14080851.
  • Nibid L, Greco C, Cordelli E, Sabarese G, Fiore M, Liu CZ, Ippolito E, Sicilia R, Miele M, Tortora M, Taffon C, Rakaee M, Soda P, Ramella S, Perrone G. Deep pathomics: A new image-based tool for predicting response to treatment in stage III non-small cell lung cancer. PLoS One. 2023 Nov 28;18(11):e0294259. doi: 10.1371/journal.pone.0294259.
  • Cortellini A, D'Alessio A, Cleary S, Buti S, Bersanelli M, Bordi P, Tonini G, Vincenzi B, Tucci M, Russo A, Pantano F, Russano M, Stucci LS, Sergi MC, Falconi M, Zarzana MA, Santini D, Spagnolo F, Tanda ET, Rastelli F, Giorgi FC, Pergolesi F, Giusti R, Filetti M, Lo Bianco F, Marchetti P, Botticelli A, Gelibter A, Siringo M, Ferrari M, Marconcini R, Vitale MG, Nicolardi L, Chiari R, Ghidini M, Nigro O, Grossi F, De Tursi M, Di Marino P, Queirolo P, Bracarda S, Macrini S, Inno A, Zoratto F, Veltri E, Spoto C, Vitale MG, Cannita K, Gennari A, Morganstein DL, Mallardo D, Nibid L, Sabarese G, Brunetti L, Perrone G, Ascierto PA, Ficorella C, Pinato DJ. Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer. Clin Cancer Res. 2023 Jul 14;29(14):2714-2724.
  • Angerilli V, Fornaro L, Pepe F, Rossi SM, Perrone G, Malapelle U, Fassan M. FGFR2 testing in cholangiocarcinoma: translating molecular studies into clinical practice. Pathological. 2023 Apr;115(2):71-82. doi: 10.32074/1591-951X-859. Epub 2023 Apr 5.
  • Nibid L, Sabarese G, Righi D, Rossi SM, Merlini G, Crucitti P, Vincenzi B, Tonini G, Perrone G. Feasibility of Comprehensive Genomic Profiling (CGP) in Real-Life Clinical Practice. Diagnostics (Basel). 2023 Feb 19;13(4):782. doi: 10.3390/diagnostics13040782.
  • Nibid L, Frasca L, Sabarese G, Righi D, Taccogna S, Crucitti P, Graziano P, Perrone G. DOG-1 positive primary acinic cell carcinoma of the lung and investigation of molecular status. Pathologica. 2022 Oct;114(5):385–390. doi: 10.32074/1591-951X-786.
  • Iorio J, Antonuzzo L, Scarpi E, D'Amico M, Duranti C, Messerini L, Sparano C, Caputo D, Lavacchi D, Borzomati D, Antonelli A, Nibid L, Perrone G, Coppola A, Coppola R, di Costanzo F, Lastraioli E, Arcangeli A. Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumors of the Ileum and Pancreas. Int J Mol Sci. 2022 Sep 13;23(18):10623. doi: 10.3390/ijms231810623.
  • Ambrosio L, Vadala G, Castaldo R, Gentile G, Nibid L, Rabitti C, Ambrosio L, Franceschetti E, Samuelsson K, Senorski EH, Papalia R, Denaro V. Massive foreign body reaction and osteolysis following primary anterior cruciate ligament reconstruction with the ligament augmentation and reconstruction system (LARS): a case report with histopathological and physicochemical analysis. BMC Musculoskeletal Disorder. 2022 Dec 30;23(1):1140. doi: 10.1186/s12891-022-05984-5.