Prof. Mario Tombini

Associate Professor for the scientific-disciplinary sector MED 26/ Neurology.

He is author/coauthor of more than 100 articles published in Med-Line, 4 book chapters.

H-index: 32 (Scopus); 31 (Web of Science).

He carries out research in the field of chronic neurological disorders, in particular epilepsy, Alzheimer's disease and sleep disorders, and more generally in clinical neurophysiology, applied to the study of various neurological diseases (including cerebrovascular diseases).

In conclusion, his research activity has focused on these topics:

1) Epilepsy and sleep disorders;

2) Clinical Neurophysiology (in particular Electroencephalogeaphy - EEG, Magnetoencephalography - MEG and Transcranial Magnetic Stimulation - TMS);

3) Dementias and Alzheimer's disease;

4) Stroke;

5) Mechanisms of brain plasticity following brain damage.

Associate Professor for the scientific-disciplinary sector MED 26/ Neurology

Assistance assignments

He works at the UOC of Neurology

Head of the Clinical Neurophysiology Laboratory, and in particular of the Electroencephalography and related techniques service, as well as Evoked Potentials.

Head of Center for the Diagnosis and Treatment of Epilepsy Epilepsy from 2019 to 2021.

Academic assignments

Professor of supplementary teaching lessons of Neurology (SSD MED/26), within the Integrated Course of Clinical Neuropsychiatry for the Specialized Degree Course in Medicine and Surgery;

Professor of "Neurology" (SSD MED/26) in the integrated course of Clinical Medicine, and of Clinical Practice for the Medicine and Surgery degree course.

Professor of 'Neurology' (SSD MED/26) and coordinator of the Integrated Course of Medical Sciences for the Degree Course in Medical Radiology Techniques for Imaging and Radiotherapy.

Professor of "Clinical Neurophysiology" (SSD MED /26) in the Neurology specialization school of the Campus Bio-Medico University.

Management or participation in editorial boards of journals:

Associate Editor of Journal of Alzheimer's Disease (from 01/01/2017)

Associate Editor of Brain Sciences (since 2020)

Associate Editor of Frontiers in Brain Imaging and Stimulation (since 2020)

Review Editor, Frontiers in Human Neuroscience Archive (since 2018)

Review Editor, Frontiers in Systems Neuroscience (since 2019)

Review Editor, Frontiers in Epilepsy (since 2019)

Training.

He attended several courses including:

-“15th UPDATE COURSE IN CLINICAL EPILEPTOLOGY” - 4thEUREPA COURSE”, Gargnano (3-10 March 2002)

- "17 COURSE IN CLINICAL ELECTROENCEPHALOGRAPHY - ADVANCED COURSE", Gargnano (2-10 March 2003)

- VIII RESIDENTIAL REFRESHING COURSE IN "EPILEPSY" (ADVANCED COURSE), Manfredonia (FG), 6-10 October 2008

- 16th Residential Course of Sleep Medicine, 14-19 April 2012 (Bertinoro -FC)

- Effective communication: how to persuade and positively influence with language, 13-14 December 2017

- Pnl and Communication, as part of the Specialization Course in Pnl and Resilience for the healthcare operator, Campus Bio-Medico University of Rome, 20 and 21 January 2018.

- Conduct of clinical trials: GCP, regulations, protocols, designs and statistics.

- ADVANCED COURSE IN HEALTHCARE MANAGEMENT, June-December 2020 (Campus Bio-Medico University)

Specialization in Neurology (October 1999- November 2004); grade: 50/50 cum laude (University of Rome "Tor Vergata"

Thesis: "Effects of acute monohemispheric stroke on spontaneous and evoked neuronal activity in the cortical representation areas of the hand: prognostic value of MEG parameters".

Degree in Medicine and Surgery. Grade: 110/110 cum laude (October 1993- July 21, 1999). Università Campus Bio-Medico di Roma

Thesis: "Cryptogenetic focal epilepsy: non-invasive neurophysiological techniques for defining the epileptogenic area"

Classical high school diploma. Vote 60/60 (1988-1993). “M. Buratti” Viterbo (VT).

1: Ricci L, Croce P, Pulitano P, Boscarino M, Zappasodi F, Narducci F, Lanzone J, Sancetta B, Mecarelli O, Di Lazzaro V, Tombini M, Assenza G. Levetiracetam Modulates EEG Microstates in Temporal Lobe Epilepsy. Brain Topogr. 2022 Nov;35(5-6):680-691.

2: Lanzone J, Boscarino M, Tufo T, Di Lorenzo G, Ricci L, Colicchio G, Di Lazzaro V, Tombini M, Assenza G. Vagal nerve stimulation cycles alter EEG connectivity in drug-resistant epileptic patients: A study with graph theory metrics. Clin Neurophysiol. 2022 Oct;142:59-67.

3: Absence G, Ricci L, Lanzone J, Boscarino M, Vico C, Narducci F, Sancetta B, Di Lazzaro V, Tombini M. Understanding and managing the impact of the COVID-19 pandemic and lockdown on patients with epilepsy. Expert Rev Neurother. 2022 Feb;22(2):145-153.

4: Croce P, Ricci L, Pulitano P, Boscarino M, Zappasodi F, Lanzone J, Narducci F, Mecarelli O, Di Lazzaro V, Tombini M, Assenza G. Machine learning for predicting levetiracetam treatment response in temporal lobe epilepsy. Clin Neurophysiol. 2021 Dec;132(12):3035-3042.

5: Lanzone J, Ricci L, Tombini M, Boscarino M, Mecarelli O, Pulitano P, Di Lazzaro V, Assenza G. The effect of Perampanel on EEG spectral power and connectivity in patients with focal epilepsy. Clin Neurophysiol. 2021 Sep;132(9):2176-2183.

6: Manhole covers M, Assenza G, Ricci L, Lanzone J, Boscarino M, Vico C, Magliozzi A, Di Lazzaro V. Temporal Lobe Epilepsy and Alzheimer's Disease: From Preclinical to Clinical Evidence of a Strong Association. J Alzheimers Dis Rep. 2021 Apr 6;5(1):243-261.

7: Lanzone J, Boscarino M, Ricci L, Insola A, Tombini M, Di Lazzaro V, Assenza G. Effects of the noncompetitive AMPA receptor antagonist perampanel on thalamocortical excitability: A study of high-frequency oscillations in somatosensory evoked potentials. Clin Neurophysiol. 2021 May;132(5):1049-1056.

8: Manhole covers M, Assenza G, Quintiliani L, Ricci L, Lanzone J, Di Lazzaro V. Epilepsy and quality of life: what does it really matter? Neurol Sci. 2021 Sep;42(9):3757-3765.

9: Ricci L, Assenza G, Pulitano P, Simonelli V, Vollero L, Lanzone J, Mecarelli O, Di Lazzaro V, Tombini M. Measuring the effects of first antiepileptic medication in Temporal Lobe Epilepsy: Predictive value of quantitative-EEG analysis. Clin Neurophysiol. 2021 Jan;132(1):25-35.

10: Manhole covers M, Assenza G, Quintiliani L, Ricci L, Lanzone J, Di Lazzaro V. Alexithymia and emotion dysregulation in adult patients with epilepsy. Epilepsy behavior. 2020 Dec;113:107537.

11: Lanzone J, Imperatori C, Assenza G, Ricci L, Farina B, Di Lazzaro V, Tombini M. Power Spectral Differences between Transient Epileptic and Global Amnesia: An eLORETA Quantitative EEG Study. Brain Sci. 2020 Sep 6;10(9):613.

12: Absence G, Lanzone J, Brigo F, Coppola A, Di Gennaro G, Di Lazzaro V, Ricci L, Romigi A, Tombini M, Mecarelli O. Epilepsy Care in the Time of COVID-19 Pandemic in Italy: Risk Factors for Seizure Worsening. Front Neurol. 2020 Jul 3;11:737.

13: Assenza G, Lanzone J, Ricci L, Boscarino M, Tombini M, Galimberti CA, Alvisi L, Tassi L, Broglia L, Di Lazzaro V, Mecarelli O. Electroencephalography at the time of Covid-19 pandemic in Italy. Neurol Sci. 2020 Aug;41(8):1999-2004.

14: Manholes M, Assenza G, Quintiliani L, Ricci L, Lanzone J, Ulivi M, Di Lazzaro V. Depressive symptoms and difficulties in emotion regulation in adult patients with epilepsy: Association with quality of life and stigma. Epilepsy behavior. 2020 Jun;107:107073.

15: Manholes M, Assenza G, Quintiliani L, Ricci L, Lanzone J, De Mojà R, Ulivi M, Di Lazzaro V. Epilepsy-associated stigma from the perspective of people with epilepsy and the community in Italy. Epilepsy behavior. 2019 Sep;98(Pt A):66-72.

16: Tombini M, Palermo A, Assenza G, Pellegrino G, Benvenga A, Campana C, Naciu AM, Assenza F, Lazzaro VD. Calcium metabolism serum markers in adult patients with epilepsy and the effect of vitamin D supplementation on seizure control. Seizure. 2018May;58:75-81.