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Pixantrone pharmacokinetics in the human heart

Multicenter study on pressure ulcers in hospice patients: prevalence, incidence and associated factors

Project objectives

The main aim of the project is to characterize the pharmacokinetics and cardiotoxic bioactivation of pixantrone in translational models of human heart exposed to doxorubicin, with the aim of interpreting the clinical cardiotolerability of pixantrone in patients with non-Hodgkin's lymphoma and previous treatments containing doxorubicin.

Start and end date

March 2010 - 2013

Project Manager

Prof. Girogio Minotti, Head of Pharmaceutical Sciences UR, Università Campus Bio-Medico di Roma and Fondazione Policlinico Universitario Campus Bio-Medico, Rome - Principal Investigator
prof Emanuela Salvatorelli, UR Pharmaceutical Sciences, Campus Bio-Medico University, Rome - Co-Principal Investigator
Prof. Pierantonio Menna, UR Clinical Pharmacology, Department of Science and Technology for Sustainable Development and One Health, Università Campus Bio-Medico di Roma; Campus Bio-Medico University Polyclinic Foundation - Co-Principal Investigator

Coordinating institution of the project

UR Pharmaceutical Sciences, Departmental Faculty of Medicine and Surgery, Integrated Research Center, Campus Bio-Medico University, Rome

Funding source(s).

• Cell Therapeutics Inc., Seattle, WA
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