Possible relationship between lysosomal acid lipase (LAL) deficiency and the development/progression of nonalcoholic fatty liver disease
Project objectives
Evaluate LAL enzymatic activity in patients with varying degrees of fatty liver disease to study the relationship between LAL deficiency and the development of NASH. Specifically, LAL enzymatic activity will be correlated with the presence of the polymorphism in exon 8 of the LIPA gene and with LAL molecular expression in the liver.
The results obtained from both enzymatic and molecular analysis will finally be correlated with the various factors of liver function and glycolipid structure and with the evolution of NAFLD.
Start and end date
Recruitment began in 2014 - December 2015
Project Manager
- prof Elisabetta Riva - molecular analysis
- Dr. U. Vespasiani - clinical part
- Prof. A. Picardi - clinical part
Project coordinating institution
Università Campus Bio-Medico di Roma
Other institutions involved in the project
Bambino Gesù Children's Hospital - Rome
Source of funding
