Evaluation of bone the quality and WNT signalling in obese patients

Project objectives

The main objective of this study is to investigate whether obesity in older people can affect bone fragility:

1. Evaluation of bone turnover and bone quality in obese subjects;
2. Study of the role of WNT signaling in the genesis of bone alterations and fractures.

Specifically, the following aspects will be examined:

1) Evaluation of bone quality in obese and elderly patients in comparison with healthy subjects.
2) Evaluation of the role of inflammation, myokines and adipokines on bone health through gene and protein expression studies.
3) Evaluation of the role of the Wnt pathway as a possible mediator of bone fragility in obese and elderly patients.

Start and end date

April 2015 - 2017

Project Manager

Prof. Nicola Napoli

Coordinating institution of the project

Università Campus Bio-Medico di Roma

Funding source(s).

Università Campus Bio-Medico di Roma