Modulating synaptic neurotransmission to reactivate the immune reaction against brain tumors

Project objectives

Glioblastoma (GB) is an aggressive brain tumor with few treatment options. Developing new therapies requires a better understanding of the two-way communication between the tumor and the surrounding brain parenchyma. On the one hand, soluble factors released by WBCs alter the balance of neuronal transmission and disrupt neural circuits; on the other hand, recent discoveries suggest that neuronal stimuli modulate the cerebral microenvironment with effects on tumor growth. In particular, our RU deals with evaluating the role of the dopaminergic system on the development of WBC.

Start and end date

February 2022 - January 2025

Project Manager

Prof. Marcello D'Amelio, Collaborator

Coordinating institution of the project

Sapienza University of Rome

Other Institutions involved

Università Campus Bio-Medico di Roma

Funding source

Ministry of University and Research

Economic value of the project

€ 166.000